Document Detail


Pregnancy in rats is modulated by ganglionic cholinergic action.
MedLine Citation:
PMID:  16735554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The control of ovarian steroidogenesis during pregnancy is mainly of endocrine origin. At present, there is little information about the influence of neural factors on the gestation physiology. The purpose of this work was to study the action of cholinergic agents in celiac ganglion upon the liberation of progesterone and ovarian androstenedione in the second half of pregnancy in rats. We used the ex vivo celiac ganglion-superior ovarian nerve-ovary integrated system (celiac ganglion-SON-ovary) that was incubated in buffer solution for 180 min, with the celiac ganglion and the ovary located in different compartments and linked by the SON. The results obtained indicate that the control values of ovarian androstenedione vary according to the pregnancy day analyzed. The addition of acetylcholine in ganglion decreased the liberation of both steroids on Day 15 whereas at the end of pregnancy it decreased the liberation of androstenedione without modifying progesterone. Due to the effect observed with atropine and hexametonium, acetylcholine action might occur through unspecific ganglionic pathways (Days 15 and 21) or through muscarinic ganglionic receptors (Days 19 and 20). Thus, we conclude that the cholinergic sympathetic system from the celiac ganglion might be a fine modulator of the pregnancy physiology.
Authors:
M Casais; S M Delgado; Z Sosa; A M Rastrilla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  131     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-31     Completed Date:  2006-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  1151-8     Citation Subset:  IM    
Affiliation:
Universidad Nacional de San Luis, Chacabuco 917, Argentina. mcasais@unsl.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Androstenedione / secretion
Animals
Atropine / pharmacology
Cholinergic Agonists / pharmacology*
Cholinergic Antagonists / pharmacology*
Female
Ganglia, Sympathetic / drug effects,  physiology*
Gestational Age
Hexamethonium / pharmacology
Models, Animal
Muscarinic Antagonists / pharmacology
Ovary / innervation,  physiology*,  secretion
Pregnancy
Progesterone / secretion
Rats
Rats, Inbred Strains
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/Cholinergic Agonists; 0/Cholinergic Antagonists; 0/Muscarinic Antagonists; 51-55-8/Atropine; 51-84-3/Acetylcholine; 57-83-0/Progesterone; 60-26-4/Hexamethonium; 63-05-8/Androstenedione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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