Document Detail

Pregnancy in rare autoimmune rheumatic diseases: UCTD, MCTD, myositis, systemic vasculitis and Beçhet disease.
MedLine Citation:
PMID:  15485105     Owner:  NLM     Status:  MEDLINE    
The physiological adaptation of the immune system to pregnancy can potentially affect the course of all autoimmune rheumatic diseases (ARD), conversely the autoimmune processes characteristic of these conditions may compromise the foetal outcome. Unfortunately, very few reports on pregnancy outcome in patients with rare ARD are available. In this paper, we briefly review the data published until now on these disorders. Some general guidelines which were elaborated for more prevalent ARD seem to be valid also for such rare conditions: 1) patients should be correctly informed on the risk of becoming pregnant; 2) pregnancies should be planned when the disease is in remission since it increases the probability of successful maternal and foetal outcome; 3) patients should be regularly monitored during gestation and postpartum by a multidisciplinary team including rheumatologist, obstetrician, and neonatologist; 4) in the case of disease relapse an adequate treatment, even aggressive if necessary, should be recommended since active disease can be more detrimental for foetus than drugs; 5) pregnancies complicated by the onset of rare ARD have a particularly severe prognosis; in these cases a prompt treatment and very close clinical surveillance are indicated.
A Doria; L Iaccarino; A Ghirardello; C Briani; S Zampieri; E Tarricone; P F Gambari
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lupus     Volume:  13     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-15     Completed Date:  2004-12-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  690-5     Citation Subset:  IM    
Division of Rheumatology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy.
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MeSH Terms
Autoimmune Diseases* / diagnosis,  therapy
Connective Tissue Diseases*
Pregnancy Complications* / diagnosis,  therapy
Rheumatic Diseases / diagnosis,  therapy

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