Document Detail

Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum.
MedLine Citation:
PMID:  15539410     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate changes in the levels of circulating cytokines with a focus on the Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS). METHODS: Plasma and serum samples of 34 pregnant patients, 19 with RA, 6 with JIA, and 9 with AS, and of 30 healthy pregnant women, 20 non-pregnant patients, and 10 non-pregnant healthy women were analysed for levels of interferon gamma (IFNgamma), interleukin (IL) 1beta, IL10, IL1 receptor antagonist (IL1Ra), soluble tumour necrosis factor receptor (sTNFR), and soluble CD30 (sCD30) by ELISA. Clinical assessment and blood sampling in pregnant women was done once in each trimester and 6, 12, and 24 weeks post partum. Disease activity in the patients was evaluated by validated clinical instruments and correlated with circulating levels of cytokines. RESULTS: Low levels of IL10 were found sporadically, whereas IFNgamma and IL1beta were below detection level in the samples tested. Significantly higher concentrations of sTNFR and IL1Ra were measured in pregnant than in non-pregnant subjects. An increase of IL1Ra from the second to the third trimester correlated with improvement of disease activity in patients with RA and AS. Compared with non-pregnant patients and the other pregnant women, patients with RA showed markedly raised levels of sCD30 during pregnancy. CONCLUSIONS: IFNgamma and IL10, markers of a Th1 and Th2 response, respectively, were either low or undetectable in the cohorts analysed. The increase of cytokine inhibitors IL1Ra and sTNFR was related to pregnancy and was independent of an underlying disease. These anti-inflammatory mediators seem to affect disease activity.
M Østensen; F Förger; J L Nelson; A Schuhmacher; G Hebisch; P M Villiger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-11
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  64     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2005-07-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  839-44     Citation Subset:  IM    
Department of Rheumatology and Clinical Immunology and Allergy, University Hospital, CH-3010 Bern, Switzerland.
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MeSH Terms
Antigens, CD30 / blood
Arthritis / immunology*
Arthritis, Juvenile Rheumatoid / immunology
Arthritis, Rheumatoid / immunology
Cytokines / blood*
Postpartum Period / immunology
Pregnancy / immunology*
Pregnancy Complications / immunology*
Prospective Studies
Receptors, Cytokine / blood
Receptors, Interleukin-1 / blood
Receptors, Tumor Necrosis Factor / blood
Spondylitis, Ankylosing / immunology
Th1 Cells / immunology
Th2 Cells / immunology
Reg. No./Substance:
0/Antigens, CD30; 0/Cytokines; 0/Receptors, Cytokine; 0/Receptors, Interleukin-1; 0/Receptors, Tumor Necrosis Factor
Comment In:
Ann Rheum Dis. 2005 Jun;64(6):801-3   [PMID:  15897301 ]

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