Document Detail

Pregnancy in patients with pulmonary autograft valve replacement.
MedLine Citation:
PMID:  9347279     Owner:  NLM     Status:  MEDLINE    
AIM: The purpose of this study is to determine the outcome and complications of pregnancy in women with pulmonary autograft valve replacement for aortic valve disease. METHODS AND RESULTS: The records of all women who had undergone pulmonary autograft valve replacement at the National Heart Hospital (now Royal Brompton Hospital) since 1968 were reviewed. From 1968 to 1993, 27 hospital survivors were female and among eight of them there were 14 pregnancies. All women were in Ability Index 1 at time of pregnancy with normal ventricular function, mild aortic regurgitation (six), mild pulmonary regurgitation (three) and mild pulmonary stenosis (two). None took anticoagulants. There was no maternal death, thromboembolic or haemorrhagic event or evidence of deterioration in valve function during pregnancy. Except for one woman (Ability Index 3) who developed dilated cardiomyopathy without aortic or pulmonary valve disease 6 months after delivery, the women remained in Ability Index 1 after pregnancy. There was no significant progression of aortic regurgitation (mild after seven pregnancies), pulmonary regurgitation (mild after six) or right-sided obstruction (mild after four). Reoperation for right-sided obstruction was carried out in two patients 4 and 7 years after a second pregnancy (9 and 15 years after the pulmonary autograft). CONCLUSION: No valve-related complications occurred during pregnancy and pregnancy appeared to have no effect on the function of the pulmonary valve autograft or the right-sided homograft. The pulmonary autograft is thus an ideal procedure for a young female needing aortic valve replacement.
A Dore; J Somerville
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  18     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-24     Completed Date:  1997-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1659-62     Citation Subset:  IM    
Grown-Up Congenital Heart (GUCH) Unit, Royal Brompton Hospital, Imperial College, London, U.K.
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MeSH Terms
Follow-Up Studies
Heart Valve Diseases / surgery,  ultrasonography
Postoperative Complications
Pregnancy Complications*
Pregnancy Outcome
Pulmonary Valve / transplantation*
Retrospective Studies
Time Factors
Transplantation, Autologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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