Document Detail


Pregnancy in patients with mechanical prosthetic heart valves. Our experience regarding 98 pregnancies in 57 patients.
MedLine Citation:
PMID:  3512575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ninety-eight pregnancies in 57 patients with mechanical (ball or tilting disc) prosthetic heart valves are described. Sixty-one pregnancies developed in 36 patients with a mitral prosthesis, 12 pregnancies in 9 patients with an aortic prosthesis, 17 pregnancies in 10 patients with both mitral and aortic prostheses and 8 pregnancies in 2 patients with mitral and tricuspid prostheses. All patients were in I or in II NYHA class at conception and no significative change was noted during pregnancy. All the patients were treated with oral anticoagulant therapy at conception. Different kinds of antithrombotic and antiembolic prophylaxis were employed. There were 13 voluntary interruptions of pregnancy and 37 spontaneous abortions. In the 47 newborn 2 malformation complications (1 warfarin syndrome, 1 cleft palate) and 4 haemorrhagic complications (without sequelae) were noted. Two fatal thromboses of a mitral prosthesis occurred; systemic embolic complications were noted in 7 cases. These observations suggested different incidences of complications regarding the antithrombotic and anti-embolic prophylaxis. The authors point out the high risk of thrombotic and embolic complications and the low rate of successful outcome of pregnancy in these patients.
Authors:
E Vitali; F Donatelli; E Quaini; G Groppelli; A Pellegrini
Related Documents :
8482305 - Myoelectric activity of an ileal isoperistaltic or antiperistaltic loop interposed betw...
1590035 - Villous hypoplasia of the small intestine in neonatal foals.
1761335 - New onset ventricular tachycardia during pregnancy.
23829325 - H435-containing immunoglobulin g3 allotypes are transported efficiently across the hu...
17626305 - The th1/th2 paradigm: still important in pregnancy?
15605595 - The effect of wax on compaction of microcrystalline cellulose beads made by extrusion a...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  27     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1986-04-10     Completed Date:  1986-04-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous
Anticoagulants / administration & dosage,  adverse effects
Congenital Abnormalities / etiology
Female
Fetal Diseases / etiology
Heart Valve Prosthesis / adverse effects*
Hemorrhage / etiology
Humans
Infant, Newborn
Infant, Newborn, Diseases / etiology
Pregnancy
Pregnancy Complications, Cardiovascular*
Risk
Thromboembolism / etiology,  prevention & control
Chemical
Reg. No./Substance:
0/Anticoagulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Errors in the differential diagnosis of incompetence of the popliteal vein and short saphenous vein ...
Next Document:  Microtubule dynamics in interphase cells.