Document Detail

Pregnancy in patients with Wegener's granulomatosis: report of five cases in three women.
MedLine Citation:
PMID:  11005781     Owner:  NLM     Status:  MEDLINE    
Five cases of pregnancy occurring in three women with previously diagnosed Wegener's granulomatosis are described. The disease was diffuse in one case and localised in the other. Initial treatment consisted of a combination of corticosteroids and intravenous cyclophosphamide in two women, and methotrexate in one. Four pregnancies ended in live births despite pre-eclampsia in two cases. One therapeutic abortion was induced because of encephalocele. Comparable reported cases were reviewed to examine the implications of immunosuppressive treatment on the fetus. A relapse occurred during pregnancy in 40% of the cases, but in 25% if only pregnancies beginning during inactive disease were taken into account. No other indicator for maternal and fetal outcome was obvious. Pregnancy should be planned after complete disappearance of disease activity. In the case of a relapse a combination of immunosuppressive drugs and corticosteroids should be chosen rather than corticosteroids alone because the outcome of pregnancy is poor in cases of undertreatment. Prematurity remains common.
C Auzary; D T Huong; B Wechsler; D Vauthier-Brouzes; J C Piette
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  59     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-06     Completed Date:  2000-11-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  800-4     Citation Subset:  IM    
Department of Internal Medicine, Hôpital de Bicêtre, 78 avenue du general leclerc, 94270 Le Kremlin-Bicetre, France.
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MeSH Terms
Abortion, Therapeutic
Encephalocele / etiology,  surgery
Fetal Macrosomia / etiology
Glucocorticoids / therapeutic use*
Immunosuppressive Agents / therapeutic use*
Obstetric Labor, Premature
Pre-Eclampsia / etiology
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Outcome
Wegener Granulomatosis / complications,  drug therapy*
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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