Document Detail

Pregnancy in liver cirrhosis. Assessment of maternal and fetal risks in eleven patients and review of the management.
MedLine Citation:
PMID:  7959326     Owner:  NLM     Status:  MEDLINE    
Eleven patients with liver cirrhosis who had a pregnancy between 1974 and 1992 are reported. Prior to pregnancy 2 patients were splenectomized, 1 of them also had an unsuccessful mesocaval shunt and therefore underwent sclerotherapy. Furthermore, 3 patients were managed by injection sclerotherapy, 6 patients had episodes of hepatocellular failure and 5 had signs of hypersplenism. Gastrointestinal hemorrhage associated with pregnancy was noted in 6 patients. Jaundice was encountered in 2 patients, a raised bilirubin level in 3, ascites in 3, impairment of the synthetic liver function in 5, thrombocytopenia in 8, hemorrhagic diathesis in 5, and infectious puerperal complication in 5 patients. Esophageal sclerotherapy was used in 5 and transfusion in 6 patients. Of 12 births, 6 newborns were small-for-date and 1 of them died. Three neonates were preterm. Fetal wastage did not occur. The present data suggest that gastrointestinal hemorrhage in liver cirrhosis contributes to developing fetal growth retardation; cirrhotic patients can be prepared for pregnancy and the hematemesis during pregnancy can successfully be managed by esophageal sclerotherapy.
A Pajor; D Lehoczky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  38     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-12     Completed Date:  1994-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
2nd Department of Obstetrics and Gynecology, Semmelweis Medical University, Budapest, Hungary.
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MeSH Terms
Fetal Growth Retardation / etiology
Gastrointestinal Hemorrhage / etiology
Infant, Newborn
Liver Cirrhosis* / complications,  therapy
Maternal Age
Pregnancy Complications* / therapy
Pregnancy Complications, Cardiovascular / etiology
Pregnancy Outcome*
Prospective Studies
Retrospective Studies
Risk Factors

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