Document Detail


Pregnancy in inherited hypokalemic salt-losing renal tubular disorder.
MedLine Citation:
PMID:  21252808     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: : The management of inherited hypokalemia has improved and the issue of pregnancy has become important.
CASES: : Between 1992 and 2010, five Italian women with the clinical diagnosis of Gitelman syndrome gave birth to a total of six newborns. Pregnancy was uneventful in four women but was complicated by tiredness and tetanic seizures in the fifth woman. Drug management included potassium chloride in four cases and magnesium and amiloride in one case each. The six neonates were born at term (n=4) or near term (n=2), with a body weight that was appropriate for gestational age. The children, aged between 6 weeks and 18 years, were healthy and neurodevelopmentally and somatically normal at the last follow-up.
CONCLUSION: : Women with hypokalemia can become pregnant and the disorder may be managed without negative effect on the fetus.
Authors:
Laura Mascetti; Alberto Bettinelli; Giacomo D Simonetti; Alessandro Tagliabue; Marie Lousie Syrén; Francesco Nordio; Mario G Bianchetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  117     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  512-6     Citation Subset:  AIM; IM    
Affiliation:
From the Division of Pediatrics, Mandic Hospital, Merate, Italy; Pediatric Nephrology, University of Bern, Bern, Switzerland; the Department of Mother-Child Sciences, University of Milan, Milan, Italy; the Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; and the Division of Pediatrics, Hospitals Mendrisio and Bellinzona, Switzerland.
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