Document Detail

Pregnancy in inflammatory bowel disease: effect of sulfasalazine and corticosteroids on fetal outcome.
MedLine Citation:
PMID:  6108894     Owner:  NLM     Status:  MEDLINE    
To determine the safety of corticosteroids and sulfasalazine in pregnancy associated with inflammatory bowel disease, we reviewed the outcome of 531 such pregnancies in a national survey. Two hundred eighty-seven pregnancies (172 ulcerative colitis and 115 Crohn's disease) were treated with either or both drugs, whereas 244 (137 ulcerative colitis and 107 Crohn's disease) received neither. The frequency of fetal complications was significantly lower in both "treated" and "untreated" groups, as compared with the reported rates in the general pregnant population. We conclude: 1. Inflammatory bowel disease, except for severe active Crohn's disease, does not seem to affect the outcome of concurrent pregnancy adversely. 2. The use of corticosteroid and sulfasalazine in pregnancy associated with ulcerative colitis is unlikely to increase the fetal morbidity or mortality. 3. Patients with severe Crohn's disease requiring corticosteroid and/or both drugs experience more complications than the "untreated" ones, but still fewer than the prevailing rates in the general pregnant population. The higher complication rate seems to be associated more with disease-related factors than the use of these drugs. 4. In the management of inflammatory bowel disease associated with pregnancy, either or both drugs may be used just as in the nonpregnant patients.
M Mogadam; W O Dobbins; B I Korelitz; S W Ahmed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  80     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenal Cortex Hormones / adverse effects*
Colitis, Ulcerative / drug therapy*
Crohn Disease / drug therapy*
Fetal Death / chemically induced
Fetus / drug effects*
Infant, Low Birth Weight
Infant, Newborn
Pregnancy Complications / drug therapy*
Sulfasalazine / adverse effects*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 599-79-1/Sulfasalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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