Document Detail


Pregnancy in dark winters: implications for fetal bone growth?
MedLine Citation:
PMID:  23040526     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To prospectively examine the prevalence of hypovitaminosis D in pregnancy and to correlate maternal and fetal vitamin D to fetal anthropometry. DESIGN: A prospective cohort study. SETTING: Tertiary referral maternity hospital. PATIENT(S): Sixty pregnant women. INTERVENTION(S): Serum 25-hydroxyvitamin D (25OHD) was measured in early pregnancy, at 28 weeks, and in cord blood at delivery. MAIN OUTCOME MEASURE(S): The prevalence of hypovitaminosis D and the relationship between fetal growth and serum 25OHD concentrations. RESULT(S): Two subgroups were analyzed to examine results in the context of seasonal variation in 25OHD: a winter and a summer cohort. Fetal anthropometry was assessed at 20 and 34 weeks, and at delivery the neonatal anthropometry was recorded. There was a high prevalence of hypovitaminosis D ranging from 33% to 97%, with a marked seasonal variation. Fetal 25OHD concentrations correlated with all biometry at 20 weeks. In the winter cohort, a correlation was found between early pregnancy 25OHD and femur length at 20 weeks, and between 28-week 25OHD and femur length at 34 weeks. Infant length was shorter in those with early pregnancy 25OHD less than the median (52.1 vs. 53.6 cm). CONCLUSION(S): The high prevalence of maternal hypovitaminosis D during winter months in northern latitudes may have detrimental effects on fetal skeletal growth.
Authors:
Jennifer M Walsh; Mark Kilbane; Ciara A McGowan; Malachi J McKenna; Fionnuala M McAuliffe
Related Documents :
4065536 - Effect of l-thyroxine on ovarian development and gestation in the viviparous guppy, poe...
20693806 - Maternal thyroid function at 11-13 weeks of gestation in women with hypothyroidism trea...
16021986 - Use of anti-thyroid drugs in euthyroid pregnant women with previous graves' disease.
20878196 - Thyroid and parathyroid surgery in pregnancy.
14623866 - Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promo...
18339486 - Colocalization of c4d deposits/cd68+ macrophages in rheumatoid nodule and granuloma ann...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury.
Next Document:  Variance in total levels of phospholipase C zeta (PLC-?) in human sperm may limit the applicability ...