Document Detail


Pregnancy in a cohort of long-term partners of human immunodeficiency virus-seropositive hemophiliacs.
MedLine Citation:
PMID:  1923188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since 1981, there have been 17 pregnancies in 12 long-term female sexual partners of human immunodeficiency virus (HIV-1)-seropositive hemophilic men at the New England Hemophilia Center. Eleven of 12 women were seronegative for HIV antibody and one was seropositive. Six of the women followed a specific antibody testing schedule for nine pregnancies. This involved antibody testing at specific points before, during, and after pregnancy. All of the seronegative women had at least one negative antibody test at the conclusion of each pregnancy. Fourteen of 16 pregnancies in the seronegative women resulted in live-born infants. The children now range in age from 7 months to 7 years and 8 months, and have no significant medical problems. The woman found to be seropositive at 8 weeks' gestation of her first pregnancy subsequently delivered an infected infant. In this small group, 11 of 12 women at risk for HIV transmission were able to become pregnant and remain seronegative for HIV antibody. Antibody testing during pregnancy gave the women information on which to base reproductive choices.
Authors:
E M Kraus; D B Brettler; A D Forsberg; J L Sullivan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  78     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-11-20     Completed Date:  1991-11-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  735-8     Citation Subset:  AIM; IM; X    
Affiliation:
Department of Medicine, Medical Center of Central Massachusetts-Memorial, Worcester.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blotting, Western
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
HIV Infections / congenital,  transmission
HIV Seropositivity*
Hemophilia A*
Humans
Infant, Newborn
Male
Maternal-Fetal Exchange
Pregnancy*
Pregnancy Complications, Infectious
Pregnancy Outcome*
Risk Factors
Sexual Partners*
Grant Support
ID/Acronym/Agency:
HL-42257/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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