Document Detail

Pregnancy in classic galactosemia despite undetectable anti-Müllerian hormone.
MedLine Citation:
PMID:  19200962     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a pregnancy in a patient with classic galactosemia despite signs of no ovarian reserve to draw attention to the limited predictive value of ovarian reserve tests in these patients. DESIGN: Case report. SETTING: Secondary and tertiary care center. PATIENT(S): A patient with classic galactosemia with premature ovarian failure and two previous pregnancies. INTERVENTION(S): Exogenous FSH ovarian reserve test and anti-Müllerian hormone (AMH) measurement. MAIN OUTCOME MEASURE(S): 17beta-Estradiol response, AMH level. RESULT(S): Pregnancy despite undetectable AMH (<0.1 microg/L) and no E(2) response (exogenous FSH ovarian reserve test). CONCLUSION(S): Fluctuating premature ovarian failure makes fertility counseling of patients with classic galactosemia difficult. Commonly used ovarian function and reserve tests seem to have no significance.
Cynthia S Gubbels; Simone M I Kuppens; Jaap A Bakker; Constantijn J A M Konings; K Will Wodzig; Monique G M de Sain-van der Velden; Paul P Menheere; M Estela Rubio-Gozalbo
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-02-07
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-05-01     Revised Date:  2009-10-05    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1293.e13-6     Citation Subset:  IM    
Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands.
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MeSH Terms
Anti-Mullerian Hormone / analysis*,  blood
Diagnostic Techniques, Endocrine
Galactosemias / blood,  complications,  diagnosis*
Ovarian Failure, Premature / blood,  diagnosis,  etiology
Pregnancy Complications / blood,  diagnosis*
Reg. No./Substance:
80497-65-0/Anti-Mullerian Hormone
Comment In:
Fertil Steril. 2009 Aug;92(2):e30; author reply e31   [PMID:  19646597 ]
Fertil Steril. 2009 Oct;92(4):e43; author reply e44   [PMID:  19733849 ]

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