Document Detail

Pregnancy in a case of Nelson's syndrome.
MedLine Citation:
PMID:  696256     Owner:  NLM     Status:  MEDLINE    
A woman suffering from Cushing's disease from the age of 17 who had been treated consecutively with pituitary irradiation, bilateral partial adrenalectomy and o,p'-DDD (Mitotane, USP) presented the clinical picture of Nelson's syndrome (hypoadrenalism with secondary hypersecretion of ACTH and MSH) at the age of 32. Under substitution therapy with corticoids she became pregnant for the first time at the age of 38. The course of the pregnancy was normal and at term she was delivered of a normal child by Cesarean section. The materno-fetal relationship, the increased risk of pituitary infarction during pregnancy and the possible teratogenic effect of chemotherapy in such cases are discussed.
S Leiba; H Kaufman; G Winkelsberg; C M Bahary
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  57     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1978  
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  373-5     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Nelson Syndrome* / drug therapy,  metabolism
Pituitary Neoplasms* / drug therapy
Pregnancy Complications* / drug therapy,  metabolism
Reg. No./Substance:
0/Adrenal Cortex Hormones

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