Document Detail

Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.
MedLine Citation:
PMID:  22270436     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity.
CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate.
CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.
Marcy Maguire; Andrea Lungu; Phillip Gorden; Elaine Cochran; Pamela Stratton
Related Documents :
24837026 - The psychological effects and patient acceptability of a test to predict viability in e...
23154616 - Maternal serum soluble endoglin at 30-33 weeks in the prediction of preeclampsia.
25021266 - 5.6 the control of hypertension in pregnancy study (chips) randomised controlled trial.
21404306 - First trimester pregnancy-associated plasma protein-a in pregnancies complicated by sub...
11316306 - Three-dimensional ultrasonography and assessment of the first-trimester fetus.
16835006 - Controlled ovarian stimulation with exclusive fsh followed by stimulation with hcg alon...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  119     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-03-25     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-5     Citation Subset:  AIM; IM    
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism
Hemoglobin A, Glycosylated / metabolism
Insulin / therapeutic use
Leptin / therapeutic use*
Lipodystrophy / blood,  congenital,  drug therapy*
Live Birth
Pregnancy Complications / blood*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Insulin; 0/Leptin
Erratum In:
Obstet Gynecol. 2013 Jul;122(1):160

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cesarean scar molar pregnancy.
Next Document:  Spleno-parametrial ectopic varices: an unusual porto-systemic shunt in portal hypertension.