Document Detail

Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.
MedLine Citation:
PMID:  22270436     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity.
CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate.
CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.
Marcy Maguire; Andrea Lungu; Phillip Gorden; Elaine Cochran; Pamela Stratton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  119     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-03-25     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-5     Citation Subset:  AIM; IM    
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814, USA.
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MeSH Terms
Blood Glucose / metabolism
Hemoglobin A, Glycosylated / metabolism
Insulin / therapeutic use
Leptin / therapeutic use*
Lipodystrophy / blood,  congenital,  drug therapy*
Live Birth
Pregnancy Complications / blood*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Insulin; 0/Leptin
Erratum In:
Obstet Gynecol. 2013 Jul;122(1):160

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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