| Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction. | |
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MedLine Citation:
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PMID: 22270436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity. CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate. CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility. |
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Authors:
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Marcy Maguire; Andrea Lungu; Phillip Gorden; Elaine Cochran; Pamela Stratton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 119 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: 2012-03-25 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 452-5 Citation Subset: AIM; IM |
Affiliation:
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Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814, USA. maguiremf@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism Female Hemoglobin A, Glycosylated / metabolism Humans Insulin / therapeutic use Leptin / therapeutic use* Lipodystrophy / blood, congenital, drug therapy* Live Birth Pregnancy Pregnancy Complications / blood* |
| Grant Support | |
ID/Acronym/Agency:
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Z99 DK999999/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Insulin; 0/Leptin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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