Document Detail

Pregnancy in Wilson's disease.
MedLine Citation:
PMID:  866569     Owner:  NLM     Status:  MEDLINE    
The effect of pregnancy has been studied in 10 mothers with Wilson's disease. Three were presymptomatic but had the typical biochemical lesion, two of these were receiving penicillamine treatment at the time of conception, the third had yet to be diagnosed. The remaining seven mothers had had symptoms of Wilson's disease and had been receiving treatment for periods ranging from two and a half to 19 years. These mothers had 15 pregnancies between them, 13 went to full term but two ended prematurely at 26 and 30 weeks. In only one did pregnancy have an unfavourable effect on the Wilson's disease; this mother had been on penicillamine for only two and a half years in a suboptimal dose because of drug induced thrombocytopoenia. In addition she had extensive oesophageal varices and pregnancy was complicated by toxaemia. The other nine patients remained well and two had three pregnancies each. On six occasions penicillamine was taken throughout pregnancy, but in seven it was discontinued from the sixth to the twelfth week. All 15 babies were normal but one died of extreme prematurity (26 weeks gestation). Pregnancy does not appear to be contraindicated in well treated Wilson's disease and penicillamine does not seem to pose an undue risk to the foetus.
J M Walshe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  46     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-83     Citation Subset:  IM    
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MeSH Terms
Ceruloplasmin / analysis
Copper / blood
Fetal Blood
Hepatolenticular Degeneration / blood,  diagnosis*,  drug therapy
Penicillamine / therapeutic use
Pregnancy Complications / blood,  diagnosis*,  drug therapy
Reg. No./Substance:
52-67-5/Penicillamine; 7440-50-8/Copper; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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