Document Detail

Pregnancy in renal transplant recipients: a UK national cohort study.
MedLine Citation:
PMID:  23085724     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Most reports of pregnancy outcome in women with kidney transplants are single-center, retrospective, and include small numbers and few are compared with controls. The aim of this study was to collect information about pregnancy outcomes among all kidney transplant recipients in the United Kingdom, managed with current antenatal and nephrologic care, and to compare these data with a contemporaneous control group.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Pregnant women with a kidney transplant were identified through the UK Obstetric Surveillance System (UKOSS) between January 1, 2007 and December 31, 2009. Data on a comparison cohort were obtained from the UKOSS database, containing information on comparison women identified in previous studies. Outcomes were also compared with national data.
RESULTS: There were 105 pregnancies identified in 101 recipients. Median prepregnancy creatinine was 118 μmol/L. Preeclampsia developed in 24% compared with 4% of the comparison group. Median gestation at delivery was 36 weeks, with 52% of women delivering at <37 weeks, significantly higher than the national rate of 8%. Twenty-four infants (24%) were small for gestational age (<10th centile). There were two (2%) cases of acute rejection. Potential predictive factors for poor pregnancy outcome included >1 previous kidney transplant (P=0.03), first trimester serum creatinine >125 μmol/L (P=0.001), and diastolic BP >90 mmHg in the second (P=0.002) and third trimesters (P=0.05).
CONCLUSIONS: Most pregnancies in the United Kingdom in women with kidney transplants are successful but rates of maternal and neonatal complications remain high.
Kate Bramham; Cathy Nelson-Piercy; Haiyan Gao; Matthias Pierce; Naomi Bush; Patsy Spark; Peter Brocklehurst; Jennifer J Kurinczuk; Marian Knight
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-18
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  8     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-08-12     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-8     Citation Subset:  IM    
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MeSH Terms
Cohort Studies
Great Britain
Kidney Transplantation*
Pregnancy Outcome*
Prospective Studies
Young Adult
Grant Support
PDA/02/06/044//Department of Health; //Department of Health
Comment In:
Clin J Am Soc Nephrol. 2013 Feb;8(2):182-3   [PMID:  23258797 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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