Document Detail


Pregnancy in Parkinson's disease: a review of the literature and a case report.
MedLine Citation:
PMID:  9452323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy is rare in Parkinson's disease (PD). In the literature on studies of antiparkinsonian drugs in animals during pregnancy, there are reports on malformations of the skeletal and circulatory system. However, the majority of studies in animals have not shown any teratogenicity. Amantadine has been teratogenic in rats and selegiline has caused neurochemical and behavioral alterations in rats when coadministered with clorgyline. The published experience with humans consists of 35 pregnancies among 26 women suffering from PD, including this report, and a number of cases treated with antiparkinsonian agents for other reasons. With the exception of the majority of the cases where amantadine was used, complications have been rare. However, there are indications that suggest a possible risk of a woman's parkinsonism worsening in connection with pregnancy. We also report the case of a woman with PD who was treated with L-dopa-benserazide during an uncomplicated pregnancy and gave birth to a healthy boy without experiencing any worsening of her PD.
Authors:
P Hagell; P Odin; E Vinge
Related Documents :
19962143 - A multidisciplinary approach to fertility-sparing therapy for a rare vulvar tumor.
33083 - Successful pregnancy following myocardial infarction: a case report.
22313653 - Spontaneous bilateral tubal pregnancy.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  13     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Affiliation:
Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced
Adjuvants, Pharmaceutic / therapeutic use
Adult
Amantadine / adverse effects
Animals
Antiparkinson Agents / therapeutic use
Benserazide / therapeutic use
Dopa Decarboxylase / antagonists & inhibitors
Dopamine Agents / therapeutic use
Enzyme Inhibitors / therapeutic use
Female
Humans
Levodopa / adverse effects
Mice
Parkinson Disease* / drug therapy
Pregnancy
Pregnancy Complications* / drug therapy
Pregnancy Outcome
Rabbits
Rats
Selegiline / adverse effects
Chemical
Reg. No./Substance:
0/Adjuvants, Pharmaceutic; 0/Antiparkinson Agents; 0/Dopamine Agents; 0/Enzyme Inhibitors; 0/Levodopa; 14611-51-9/Selegiline; 322-35-0/Benserazide; 768-94-5/Amantadine; EC 4.1.1.-/Dopa Decarboxylase
Comments/Corrections
Comment In:
Mov Disord. 1999 Jan;14(1):194   [PMID:  9918378 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Depression in classic versus akinetic-rigid Parkinson's disease.
Next Document:  Ropinirole in the treatment of early Parkinson's disease: a 6-month interim report of a 5-year levod...