| Pregnancy in Parkinson's disease: a review of the literature and a case report. | |
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MedLine Citation:
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PMID: 9452323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy is rare in Parkinson's disease (PD). In the literature on studies of antiparkinsonian drugs in animals during pregnancy, there are reports on malformations of the skeletal and circulatory system. However, the majority of studies in animals have not shown any teratogenicity. Amantadine has been teratogenic in rats and selegiline has caused neurochemical and behavioral alterations in rats when coadministered with clorgyline. The published experience with humans consists of 35 pregnancies among 26 women suffering from PD, including this report, and a number of cases treated with antiparkinsonian agents for other reasons. With the exception of the majority of the cases where amantadine was used, complications have been rare. However, there are indications that suggest a possible risk of a woman's parkinsonism worsening in connection with pregnancy. We also report the case of a woman with PD who was treated with L-dopa-benserazide during an uncomplicated pregnancy and gave birth to a healthy boy without experiencing any worsening of her PD. |
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Authors:
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P Hagell; P Odin; E Vinge |
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19962143 - A multidisciplinary approach to fertility-sparing therapy for a rare vulvar tumor. 33083 - Successful pregnancy following myocardial infarction: a case report. 22313653 - Spontaneous bilateral tubal pregnancy. |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 13 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-26 Completed Date: 1998-03-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced Adjuvants, Pharmaceutic / therapeutic use Adult Amantadine / adverse effects Animals Antiparkinson Agents / therapeutic use Benserazide / therapeutic use Dopa Decarboxylase / antagonists & inhibitors Dopamine Agents / therapeutic use Enzyme Inhibitors / therapeutic use Female Humans Levodopa / adverse effects Mice Parkinson Disease* / drug therapy Pregnancy Pregnancy Complications* / drug therapy Pregnancy Outcome Rabbits Rats Selegiline / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Pharmaceutic; 0/Antiparkinson Agents; 0/Dopamine Agents; 0/Enzyme Inhibitors; 0/Levodopa; 14611-51-9/Selegiline; 322-35-0/Benserazide; 768-94-5/Amantadine; EC 4.1.1.-/Dopa Decarboxylase |
| Comments/Corrections | |
Comment In:
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Mov Disord. 1999 Jan;14(1):194
[PMID:
9918378
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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