Document Detail

Pregnancy in Parkinson's disease: a review of the literature and a case report.
MedLine Citation:
PMID:  9452323     Owner:  NLM     Status:  MEDLINE    
Pregnancy is rare in Parkinson's disease (PD). In the literature on studies of antiparkinsonian drugs in animals during pregnancy, there are reports on malformations of the skeletal and circulatory system. However, the majority of studies in animals have not shown any teratogenicity. Amantadine has been teratogenic in rats and selegiline has caused neurochemical and behavioral alterations in rats when coadministered with clorgyline. The published experience with humans consists of 35 pregnancies among 26 women suffering from PD, including this report, and a number of cases treated with antiparkinsonian agents for other reasons. With the exception of the majority of the cases where amantadine was used, complications have been rare. However, there are indications that suggest a possible risk of a woman's parkinsonism worsening in connection with pregnancy. We also report the case of a woman with PD who was treated with L-dopa-benserazide during an uncomplicated pregnancy and gave birth to a healthy boy without experiencing any worsening of her PD.
P Hagell; P Odin; E Vinge
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  13     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.
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MeSH Terms
Abnormalities, Drug-Induced
Adjuvants, Pharmaceutic / therapeutic use
Amantadine / adverse effects
Antiparkinson Agents / therapeutic use
Benserazide / therapeutic use
Dopa Decarboxylase / antagonists & inhibitors
Dopamine Agents / therapeutic use
Enzyme Inhibitors / therapeutic use
Levodopa / adverse effects
Parkinson Disease* / drug therapy
Pregnancy Complications* / drug therapy
Pregnancy Outcome
Selegiline / adverse effects
Reg. No./Substance:
0/Adjuvants, Pharmaceutic; 0/Antiparkinson Agents; 0/Dopamine Agents; 0/Enzyme Inhibitors; 0/Levodopa; 14611-51-9/Selegiline; 322-35-0/Benserazide; 768-94-5/Amantadine; EC 4.1.1.-/Dopa Decarboxylase
Comment In:
Mov Disord. 1999 Jan;14(1):194   [PMID:  9918378 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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