| Pregnancy in Marfan syndrome after aortic root replacement: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 18377545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Marfan syndrome is an inheritable connective tissue disorder with multisystem involvement and variable expression of signs and symptoms, caused by mutations within the fibrillin gene on chromosome 15q21. The reported incidence of severe cardiovascular events during pregnancy in Marfan patients' series is 3-7%, and the overall risk of fatal complication is approximately 1%. Although acute aortic dissection is a rare complication, an association between pregnancy and aortic dissection has been reported even in the absence of preconception aortic root dilatation. DESIGN: Case report and literature review. RESULTS: A 29-year-old pregnant woman with Marfan syndrome after replacement of ascending aorta with aortic valve conservation. She had a normal pregnancy and was delivered at term by cesarean section. CONCLUSION: Successful pregnancy and delivery can be achieved in Marfan's patients after aortic root replacement. |
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Authors:
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Vania Volach; Amir Elami; Dan Gilon; Arthur Pollak; Yehuda Ginosar; Yossef Ezra |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Congenital heart disease Volume: 1 ISSN: 1747-0803 ISO Abbreviation: - Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 184-8 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Adult Aneurysm, Dissecting / prevention & control* Antihypertensive Agents / therapeutic use Aortic Diseases / etiology, surgery* Blood Vessel Prosthesis* Delivery, Obstetric Dilatation, Pathologic Female Humans Hydralazine / therapeutic use Marfan Syndrome / complications, surgery* Pregnancy Pregnancy Complications, Cardiovascular / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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