Document Detail

Pregnancy in B-cell-deficient mice: postpartum transfer of immunoglobulins prevents neonatal runting and death.
MedLine Citation:
PMID:  7888494     Owner:  NLM     Status:  MEDLINE    
Mice lacking functional B cells because of a genetic deletion of the mu chain (IgM) gene were used to investigate the role of perinatal and postnatal transfer of maternal IgG in neonatal growth. Our results confirmed that immunoglobulin (Ig)-deficient mice successfully complete pregnancy and deliver healthy offspring. However, neonates nursed by Ig-deficient mothers showed growth retardation (runting) and high mortality during their first 10 days of life. This fatal course was seen whether or not the neonates were Ig-deficient. Cross-switching litters from phenotypically normal mothers to Ig-deficient mothers immediately after birth showed that perinatal Ig transfer normalized neonatal development for 10 days, but was not sufficient to sustain survival during the later part of the neonatal period. On the other hand, all Ig-deficient litters nursed by normal foster mothers showed normal development and 0% neonatal mortality. Administration of mouse IgG to an Ig-deficient mother or a neonate during the first critical week prevented runting. We assume that the growth- and health-promoting effects of IgG during early neonatal life are attributable mainly to the transfer of passive immunity to environmental pathogens. However, the finding that monoclonal IgG antibodies also enhanced neonatal growth and survival suggests that IgG-dependent growth-promoting mechanisms could be involved as well.
E Gustafsson; A Mattsson; R Holmdahl; R Mattsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of reproduction     Volume:  51     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1173-80     Citation Subset:  IM    
Department of Animal Development and Genetics, Uppsala University, Sweden.
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MeSH Terms
Animals, Newborn / growth & development,  immunology*,  physiology
B-Lymphocytes / cytology,  immunology,  physiology
Base Sequence
DNA Primers / analysis,  chemistry,  genetics
Enzyme-Linked Immunosorbent Assay
Fetal Death / prevention & control
Growth Disorders / prevention & control*
Immunity, Maternally-Acquired / immunology
Immunoglobulin G / genetics,  immunology,  physiology
Immunoglobulin M / genetics,  immunology,  physiology
Immunoglobulins / analysis,  metabolism,  physiology*
Immunologic Deficiency Syndromes / genetics,  mortality*
Lactation / immunology
Lymphocyte Count
Mice, Mutant Strains / immunology*
Molecular Sequence Data
Polymerase Chain Reaction
Postpartum Period / immunology
Pregnancy, Animal / immunology*,  physiology
Reg. No./Substance:
0/DNA Primers; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins

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