Document Detail

Pregnancy improves neutropenia in T-cell large granular lymphocyte leukaemia.
MedLine Citation:
PMID:  15725086     Owner:  NLM     Status:  MEDLINE    
The effect of pregnancy on T-cell large granular lymphocyte (LGL) leukaemia has not been previously described. We retrospectively reviewed the clinical features of three patients with T-cell LGL leukaemia; each of them had one or more pregnancies during disease evolution. Pregnancy was associated with sustained improvement in neutrophil count and concurrent reduction in lymphocytosis. Neutropenia returned in the non-pregnant state in all cases. A similar effect, induced by exogenous progesterone in one patient, suggests a role for progesterone in overcoming mechanisms of neutropenia in this disease. Pregnancy thus appears to have a beneficial effect on neutrophil count in T-cell LGL leukaemia.
Nnenna Osuji; Estella Matutes; Claire Dearden; Daniel Catovsky
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  128     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  645-8     Citation Subset:  IM    
Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Surrey SM2 5PT, UK.
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MeSH Terms
Cyclosporine / therapeutic use
Immunosuppressive Agents / therapeutic use
Leukemia, Prolymphocytic, T-Cell / drug therapy,  immunology*,  metabolism
Leukocyte Count
Neutropenia / metabolism
Pregnancy Complications, Neoplastic / drug therapy,  immunology*,  metabolism
Progesterone / metabolism
Retrospective Studies
Reg. No./Substance:
0/Immunosuppressive Agents; 57-83-0/Progesterone; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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