Document Detail


Pregnancy hypertension, blood pressure during labor, and blood lead levels.
MedLine Citation:
PMID:  3653974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy hypertension, blood pressure during labor, and the umbilical cord blood lead concentration were assessed in 3851 women for whom additional demographic, medical, and personal information was available. Lead levels correlated with both systolic (Pearson r = 0.081, p = 0.0001) and diastolic (r = 0.051, p = 0.002) blood pressures during labor. The incidence of pregnancy hypertension increased with lead level. Multivariate models of pregnancy hypertension and systolic blood pressure as a function of maternal age, parity, hematocrit, ponderal index, race, and diabetes were improved by including lead as a predictor variable. At these observed levels of exposure (mean blood lead, 6.9 +/- 3.3 [SD] micrograms/dl), lead appears to have a small but demonstrable association with pregnancy hypertension and blood pressure at the time of delivery, but not with preeclampsia.
Authors:
M Rabinowitz; D Bellinger; A Leviton; H Needleman; S Schoenbaum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  10     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-16     Completed Date:  1987-11-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  IM    
Affiliation:
Mental Retardation Research Center, Children's Hospital and Harvard Medical School, Boston, MA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetal Blood / analysis
Humans
Hypertension / chemically induced*
Lead / blood
Lead Poisoning / complications*
Obstetric Labor Complications / chemically induced*
Pregnancy
Pregnancy Complications, Cardiovascular / chemically induced*
Grant Support
ID/Acronym/Agency:
HD-08945/HD/NICHD NIH HHS; HD-17407/HD/NICHD NIH HHS; HD-20381/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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