Document Detail


Pregnancy and human herpesvirus 8 reactivation in human immunodeficiency virus type 1-infected women.
MedLine Citation:
PMID:  16943357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the impact of pregnancy on human herpesvirus 8 (HHV-8) reactivation in human immunodeficiency virus type 1 (HIV-1)-infected women, the HHV-8 DNA presence and load were analyzed in peripheral blood mononuclear cells (PBMCs) and cervicovaginal secretions (CVSs) from 15 pregnant women coinfected with HIV-1 and HHV-8. HHV-8 detection was analyzed in relation to anti-HHV-8 antibodies and HIV-1-related parameters. Nucleotide sequence analysis of an ORFK1 hypervariable region of the HHV-8 strains was performed. HHV-8 was detected in maternal PBMCs (5/15 women) from the second trimester and in CVSs (5/15 women) mainly from the third trimester. The HHV-8 load significantly increased late in pregnancy in both maternal compartments and was associated with a significant increase in HIV-1 shedding in the genital tract. Antilytic antibodies were significantly more common in HHV-8 DNA-positive women. An elevated HHV-8 load was found in the PBMCs of an infant born to a mother with large amounts of HHV-8 in both compartments at delivery. Different ORFK1 subtypes were found in maternal samples, whereas the same subtype was identified in the mother-child pair. These data suggest that pregnancy may induce HHV-8 replication in HIV-1-infected women. An augmented HHV-8 load may, in turn, influence mother-to-child transmission, since one of the HIV-1-infected mothers with HHV-8 reactivation transmitted her ORFK1 subtype to the infant, who showed a high level of HHV-8 viremia indicative of a primary infection. This finding documents for the first time the perinatal transmission of a specific HHV-8 subtype. Vertical transmission may thus play a role in HHV-8 spread also in areas of subendemicity among HIV-1-infected women.
Authors:
Andrea Lisco; Massimo Barbierato; Josè R Fiore; Paola Gasperini; Anna Favia; Anna Volpe; Maria Chironna; Giuseppe Pastore; Luigi Chieco-Bianchi; Maria Luisa Calabrò
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-30
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  44     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2006-12-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3863-71     Citation Subset:  IM    
Affiliation:
Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padua, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / virology*
Adult
Amino Acid Sequence
Base Sequence
DNA, Viral / blood
Female
HIV-1*
Herpesvirus 8, Human / isolation & purification*,  physiology
Humans
Infant, Newborn
Leukocytes, Mononuclear / virology
Molecular Sequence Data
Polymerase Chain Reaction
Pregnancy
Pregnancy Complications, Infectious / virology*
Virus Activation*
Virus Shedding
Chemical
Reg. No./Substance:
0/DNA, Viral
Comments/Corrections

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