| Pregnancy and human herpesvirus 8 reactivation in human immunodeficiency virus type 1-infected women. | |
| | |
MedLine Citation:
|
PMID: 16943357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To investigate the impact of pregnancy on human herpesvirus 8 (HHV-8) reactivation in human immunodeficiency virus type 1 (HIV-1)-infected women, the HHV-8 DNA presence and load were analyzed in peripheral blood mononuclear cells (PBMCs) and cervicovaginal secretions (CVSs) from 15 pregnant women coinfected with HIV-1 and HHV-8. HHV-8 detection was analyzed in relation to anti-HHV-8 antibodies and HIV-1-related parameters. Nucleotide sequence analysis of an ORFK1 hypervariable region of the HHV-8 strains was performed. HHV-8 was detected in maternal PBMCs (5/15 women) from the second trimester and in CVSs (5/15 women) mainly from the third trimester. The HHV-8 load significantly increased late in pregnancy in both maternal compartments and was associated with a significant increase in HIV-1 shedding in the genital tract. Antilytic antibodies were significantly more common in HHV-8 DNA-positive women. An elevated HHV-8 load was found in the PBMCs of an infant born to a mother with large amounts of HHV-8 in both compartments at delivery. Different ORFK1 subtypes were found in maternal samples, whereas the same subtype was identified in the mother-child pair. These data suggest that pregnancy may induce HHV-8 replication in HIV-1-infected women. An augmented HHV-8 load may, in turn, influence mother-to-child transmission, since one of the HIV-1-infected mothers with HHV-8 reactivation transmitted her ORFK1 subtype to the infant, who showed a high level of HHV-8 viremia indicative of a primary infection. This finding documents for the first time the perinatal transmission of a specific HHV-8 subtype. Vertical transmission may thus play a role in HHV-8 spread also in areas of subendemicity among HIV-1-infected women. |
| | |
Authors:
|
Andrea Lisco; Massimo Barbierato; Josè R Fiore; Paola Gasperini; Anna Favia; Anna Volpe; Maria Chironna; Giuseppe Pastore; Luigi Chieco-Bianchi; Maria Luisa Calabrò |
Related Documents
:
|
3963087 - Meningoencephalitis caused by histoplasma capsulatum complicating pregnancy. 16083057 - Congenital trichinellosis in experimentally infected mice. 2480777 - An experimental study on the effects of elastase, bleomycin and infection on the growth... 6986087 - A prospective study of acquired toxoplasmosis among 8,043 pregnant women in the oslo area. 3929327 - Endometrial echo and its significance in female infertility. 12963507 - Clinical audit: obstetric performance after caesarean section. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-30 |
Journal Detail:
|
Title: Journal of clinical microbiology Volume: 44 ISSN: 0095-1137 ISO Abbreviation: J. Clin. Microbiol. Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2006-11-07 Completed Date: 2006-12-22 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505564 Medline TA: J Clin Microbiol Country: United States |
Other Details:
|
Languages: eng Pagination: 3863-71 Citation Subset: IM |
Affiliation:
|
Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padua, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acquired Immunodeficiency Syndrome
/
virology* Adult Amino Acid Sequence Base Sequence DNA, Viral / blood Female HIV-1* Herpesvirus 8, Human / isolation & purification*, physiology Humans Infant, Newborn Leukocytes, Mononuclear / virology Molecular Sequence Data Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious / virology* Virus Activation* Virus Shedding |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of three commercial assays and a modified disk diffusion assay with two broth microdiluti...
Next Document: Multiplex PCR-based method for identification of common clinical serotypes of Salmonella enterica su...