| Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosis. | |
MedLine Citation:
|
PMID: 21079181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) in all pregnancies occurring in women with multiple sclerosis (MS) during the study period, with a specific focus on the risk of spontaneous abortion. METHODS: In this cohort study, data were gathered through a standardized, semi-structured interview. Patients who discontinued IFNβ less than 4 weeks from conception (exposed) were compared with those who had discontinued the drug at least 4 weeks from conception or who were never treated (not exposed). Possible confounders were handled through multivariate analyses adjusted for propensity score (PS). RESULTS: We collected data on 396 pregnancies in 388 women, 88 classified as exposed (mean exposure 4.6 ± 5.8 weeks). IFNβ exposure was not associated with an increased risk of spontaneous abortion (PS-adjusted odds ratio [OR] 1.08, 95% confidence interval [CI] 0.4 to 2.9, p = 0.88), although it was associated with both lower baby weight (PS-adjusted β -113.8, p < 0.0001) and length (PS-adjusted β -1.102, p < 0.0001). Proportion of spontaneous abortion in exposed patients fell within the range expected for the Italian population in the same period. IFNβ exposure (PS-adjusted OR 2.11, 95% CI 1.18 to 3.78, p = 0.012) and cesarean delivery were the only predictors of preterm delivery. In the exposed group, we did not observe any significant fetal complications, malformations, or developmental abnormalities over a median follow-up of 2.1 years. CONCLUSIONS: Our findings point to the relative safety of IFNβ exposure times of up to 4 weeks and can assist neurologists facing therapeutic decisions in women with MS with a pregnancy plan. |
Authors:
|
M P Amato; E Portaccio; A Ghezzi; B Hakiki; V Zipoli; V Martinelli; L Moiola; F Patti; L La Mantia; G L Mancardi; C Solaro; M R Tola; C Pozzilli; L De Giglio; R Totaro; A Lugaresi; V Di Tommaso; D Paolicelli; M G Marrosu; G Comi; F Pellegrini; M Trojano; |
Publication Detail:
|
Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
|
Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-16 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 1794-802 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, University of Florence, Florence, Italy. mariapia.amato@unifi.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Spontaneous
/
chemically induced*,
etiology,
physiopathology Adult Cohort Studies Female Fetal Diseases / chemically induced, diagnosis, physiopathology Fetal Weight / drug effects Follow-Up Studies Humans Infant, Newborn Interferon-beta / adverse effects, therapeutic use* Male Multiple Sclerosis / complications, drug therapy* Pregnancy Pregnancy Outcome / epidemiology Prospective Studies |
| Chemical | |
Reg. No./Substance:
|
77238-31-4/Interferon-beta |
| Investigator | |
Investigator/Affiliation:
|
Maria Pia Amato / ; Emilio Portaccio / ; Bahia Hakiki / ; Valentina Zipoli / ; Gianfranco Siracusa / ; Angelo Ghezzi / ; Annalisa Rizzo / ; Mauro Zaffaroni / ; Vittorio Martinelli / ; Marta Radaelli / ; Lucia Moiola / ; Giancarlo Comi / ; Clara Milanese / ; Loredana La Mantia / ; Alessandra Protti / ; Chiara Spreafico / ; Raffaella Marazzi / ; Paola Cavalla / ; Silvia Masera / ; Roberto Bergamaschi / ; Gian Luigi Mancardi / ; Elisabetta Capello / ; Claudio Solaro / ; Federica Molinari / ; Maria Rosaria Tola / ; Luisa Caniatti / ; Franco Granella / ; Paolo Immovilli / ; Pasquale Annunziata / ; Lorenzo De Santi / ; Katrin Plewnia / ; Leonello Guidi / ; Maria Letizia Bartolozzi / ; Monica Mazzoni / ; Carlo Pozzilli / ; Laura De Giglio / ; Rocco Totaro / ; Alessandra Lugaresi / ; Valeria Di Tommaso / ; Giovanna De Luca / ; Maria Trojano / ; Damiano Paolicelli / ; Alessandro Carrozzo / ; Mariangela D'Onghia / ; Maria Giovanna Marrosu / ; Luigina Musu / ; Francesco Patti / ; Tiziana Cavallaro / ; Fabio Pellegrini / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study.
Next Document: Vesicular glutamate transporter and cognition in stroke: a case-control autopsy study.