Document Detail

Pregnancy estrogens in relation to coffee and alcohol intake.
MedLine Citation:
PMID:  1342274     Owner:  NLM     Status:  MEDLINE    
Total estrogen (TE), estradiol (E2), estriol (E3), and human placental lactogen (hPL) levels were determined by radioimmunoassay in the blood of 141 pregnant women during their 26th and 31st weeks of pregnancy and the results were studied in relation to coffee and alcohol intake. After controlling for maternal age, maternal weight at the corresponding week of pregnancy, parity, and tobacco smoking, as well as for mutual confounding effects, coffee intake, ascertained at the 26th week, was found to be negatively related to pregnancy E2 levels (P = 0.04 during the 26th week, and P = .16 during the 31st week), whereas alcohol intake, also ascertained at the 26th week, was found to be positively related to pregnancy TE levels (P = .04 during the 26th week, and P = .18 during the 31st week). The negative relation between coffee consumption on the one hand and E2 (and possibly TE) levels on the other may be responsible for the inverse association between maternal coffee intake and birth weight; the latter association has been repeatedly confirmed in the literature, although it was neither strong nor statistically significant in the present study. The relations of maternal coffee and alcohol consumption with pregnancy estrogen levels, if confirmed, could be utilized in studies exploring the role of prenatal exposure to these hormones in the etiology of gonadal germ-cell tumors and possibly other diseases.
E Petridou; K Katsouyanni; E Spanos; Y Skalkidis; K Panagiotopoulou; D Trichopoulos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of epidemiology     Volume:  2     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  1992 May 
Date Detail:
Created Date:  1994-02-10     Completed Date:  1994-02-10     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-7     Citation Subset:  IM    
Department of Hygiene and Epidemiology, University of Athens Medical School, Greece.
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MeSH Terms
Alcohol Drinking* / adverse effects
Birth Weight
Body Weight
Coffee* / adverse effects
Estradiol / blood
Estriol / blood
Estrogens / blood*
Infant, Newborn
Maternal Age
Placental Lactogen / blood
Pregnancy / blood*
Reg. No./Substance:
0/Coffee; 0/Estrogens; 50-27-1/Estriol; 50-28-2/Estradiol; 9035-54-5/Placental Lactogen

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