Document Detail


Pregnancy and estrogen receptor beta expression in a large congenital nevus.
MedLine Citation:
PMID:  19528425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Large congenital nevi carry a slightly increased risk of melanoma. Pregnancy poses an additional challenge in the monitoring of these patients because little is known regarding the effects of increased estrogen levels on congenital nevi.
OBSERVATIONS: A young woman was observed to have clinical lightening of her garment nevus and satellite nevi during 2 sequential pregnancies. Postpartum, the patient experienced darkening and repigmentation in her large garment nevus, with continued lightening of nearby satellite lesions. In addition to photographic documentation of these changes, biopsy samples taken during pregnant and nonpregnant periods underwent immunohistochemical evaluation for estrogen receptor beta (ERbeta), the predominant estrogen receptor in nevi and melanomas. Biopsy samples collected during pregnancy showed a decrease in nuclear staining for ERbeta compared with samples collected after pregnancy. These changes in ERbeta expression were not associated with histologic atypia during pregnancy or after delivery.
CONCLUSIONS: Congenital nevi may be unique in their response to altered estrogen levels. Given the slightly increased risk of melanoma in giant congenital nevi and the dearth of information available regarding the effects of pregnancy on congenital nevi, this case illustrates the need for further study of these pigmented lesions.
Authors:
Mary Alice Nading; Lillian B Nanney; Darrel L Ellis
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of dermatology     Volume:  145     ISSN:  1538-3652     ISO Abbreviation:  Arch Dermatol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-07-15     Revised Date:  2013-12-25    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Biopsy, Needle
Estrogen Receptor beta / blood,  metabolism*
Female
Follow-Up Studies
Gestational Age
Humans
Immunohistochemistry
Nevus, Pigmented / congenital,  metabolism*,  pathology
Parity
Pregnancy
Pregnancy Complications, Neoplastic / metabolism*,  pathology
Pregnancy Outcome*
Risk Assessment
Skin Neoplasms / congenital,  metabolism*,  pathology
Young Adult
Grant Support
ID/Acronym/Agency:
5P30 AR041943/AR/NIAMS NIH HHS; P30 AR041943/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Estrogen Receptor beta
Comments/Corrections

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