| Pregnancy, epilepsy, management and outcome: a 10-year perspective. | |
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MedLine Citation:
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PMID: 8162395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analysed the management and outcome of 348 pregnancies in 207 women with epilepsy from 1977 to 1981 and 1987 to 1991. Outcome was successful in 88%. There was a marked change in anticonvulsant prescribing away from phenobarbitone and phenytoin towards carbamazepine and sodium valproate but a large number of patients (24%) were treated with two or more anticonvulsants in the second cohort despite a move towards monotherapy. A significant reduction in congenital malformation (4.8%), spontaneous abortion (6.9%) or low birth weight babies (9.4%) was not seen. Until experience is gained with the newer agents, monotherapy remains of major importance in the management of the pregnant woman with epilepsy. |
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Authors:
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P J Martin; P A Millac |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 2 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-05-25 Completed Date: 1994-05-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 277-80 Citation Subset: IM |
Affiliation:
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Department of Neurology, Leicester Royal Infirmary, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Anticonvulsants / adverse effects*, therapeutic use Birth Weight / drug effects Carbamazepine / adverse effects, therapeutic use Cohort Studies Drug Therapy, Combination Epilepsy / drug therapy* Female Humans Infant, Newborn Phenytoin / adverse effects, therapeutic use Pregnancy Pregnancy Complications / drug therapy* Pregnancy Outcome* Risk Factors Valproic Acid / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 298-46-4/Carbamazepine; 57-41-0/Phenytoin; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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