Document Detail

Pregnancy and economic outcomes in patients treated for recurrent preterm labor.
MedLine Citation:
PMID:  14999214     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare clinical and cost-effectiveness of treating recurrent preterm labor (RPTL) with oral nifedipine versus continuous subcutaneous terbutaline infusion (SQT). STUDY DESIGN: Women with singleton gestations prescribed nifedipine for tocolysis following first diagnosis of preterm labor were identified. Women hospitalized with RPTL at <34 weeks were matched by gestational age (GA) after resuming nifedipine (NIF group) with women prescribed SQT (SQT group) after stabilization. Healthcare utilization costs were modeled and compared. RESULTS: This study analyzed 142 matched pairs. GA at RPTL (matched variable) was 30.4+/-2.6 weeks. GA at delivery was earlier in the NIF group versus the SQT group (35.7+/-3.1 weeks versus 36.6+/-2.1 weeks, p=0.004). Overall, infants from the NIF group had lower birth weights and higher nursery days than infants from the SQT group. Healthcare utilization costs were greater in the NIF group versus the SQT group (37,040+/-47,518 US dollars versus 26,546+/-25,386 US dollars, p=0.014). CONCLUSION: Treating RPTL with SQT versus oral nifedipine resulted in a later GA at delivery, improved neonatal outcome, and increased cost-effectiveness.
Alfred Fleming; Robert Bonebrake; Niki Istwan; Debbie Rhea; Suzanne Coleman; Gary Stanziano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  24     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-07-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Creighton University Medical Center, Omaha, NE 68131, USA.
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MeSH Terms
Administration, Oral
Case-Control Studies
Cost-Benefit Analysis
Costs and Cost Analysis
Infusion Pumps, Implantable
Nifedipine / administration & dosage,  therapeutic use*
Obstetric Labor, Premature / economics*,  prevention & control*
Pregnancy Outcome*
Retrospective Studies
Terbutaline / administration & dosage,  therapeutic use*
Tocolysis / economics*,  methods
Tocolytic Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Tocolytic Agents; 21829-25-4/Nifedipine; 23031-25-6/Terbutaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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