Document Detail


Pregnancy during adolescence has lasting adverse effects on blood lipids: a 10-year longitudinal study of black and white females.
MedLine Citation:
PMID:  22385547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Primiparity has been associated with 3 to 4 mg/dL lower high-density lipoprotein cholesterol concentrations in black and white adult women that persist several years after delivery.
OBJECTIVE: To examine the lasting effects of adolescent pregnancy on blood lipids, an early risk factor for future cardiometabolic diseases.
DESIGN: The National Heart Lung and Blood Institute's Growth and Health Study is a multicenter prospective cohort that measured fasting blood lipids for 1013 (513 black, 500 white) participants at baseline (1987-1988) ages 9-10, and again at follow-up (1996-1997) ages 18-19.
METHODS: Change in fasting plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, defined as the difference between baseline and follow-up measurements, was compared among 186 (145 black, 41 white) primi- or multiparas, 106 (55 black, 51 white) nulliparous, gravidas versus 721 (313 black, 408 white) nulligravidas. Fully adjusted multiple linear regression models estimated blood lipid changes among these pregnancy groups adjusted for race, age at menarche, baseline lipids, physical inactivity, body mass index, and family sociodemographics.
RESULTS: In the 10-year study period, adolescent paras compared with nulligravidas had greater decrements in high-density lipoprotein cholesterol (mg/dL; fully adjusted mean [95% confidence interval] group differences in black -4.3 [-6.7, -2.0]; P < .001 and white: -4.5 [-8.2, -0.7]; P = .016) and greater increments in fasting triglycerides (mg/dL; adjusted mean [95% confidence interval] group differences in black: 10.4 [3.9, 16.8]; P < .001, and white: 11.6 [-3.6, 26.8]; P = .167).
CONCLUSION: Adolescent pregnancy contributes to pro-atherogenic lipid profiles that persist after delivery. Further research is needed to assess whether adolescent pregnancy has implications for future cardiovascular disease risk in young women.
Authors:
Erica P Gunderson; George Schreiber; Ruth Striegel-Moore; Mark Hudes; Stephen Daniels; Frank M Biro; Patricia B Crawford
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-23
Journal Detail:
Title:  Journal of clinical lipidology     Volume:  6     ISSN:  1933-2874     ISO Abbreviation:  J Clin Lipidol     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-07-13     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  101300157     Medline TA:  J Clin Lipidol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-49     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 National Lipid Association. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
African Continental Ancestry Group*
Child
Contraception / statistics & numerical data
European Continental Ancestry Group*
Female
Gravidity
Humans
Lipids / blood*
Longitudinal Studies
Multivariate Analysis
Parity
Pregnancy / blood*,  physiology
Young Adult
Grant Support
ID/Acronym/Agency:
K01 DK059944/DK/NIDDK NIH HHS; K01 DK059944-05/DK/NIDDK NIH HHS; N01-HC-55023-26/HC/NHLBI NIH HHS; R01 HD039304/HD/NICHD NIH HHS; R01 HD039304-03/HD/NICHD NIH HHS; R01 HD39304/HD/NICHD NIH HHS; R01 MH57897/MH/NIMH NIH HHS; UL1 TR000077/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Lipids
Comments/Corrections

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