Document Detail

Pregnancy during TNFalpha antagonist therapy: beware the rifampin-oral contraceptive interaction. Report of two cases.
MedLine Citation:
PMID:  20447852     Owner:  NLM     Status:  MEDLINE    
We report two cases of pregnancy in patients taking TNFalpha antagonists for chronic inflammatory joint disease. A factor in both pregnancies was the use of rifampin concomitantly with a combined oral contraceptive. Both patients were taking rifampin and isoniazid for tuberculosis prophylaxis in compliance with French recommendations for patients with positive intradermal tuberculin tests who are scheduled to receive biotherapeutic agents.
Cécile Wibaux; Irina Andrei; Julien Paccou; Peggy Philippe; Emmanuel Biver; Bernard Duquesnoy; René Marc Flipo
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-05
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  77     ISSN:  1778-7254     ISO Abbreviation:  Joint Bone Spine     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  France    
Other Details:
Languages:  eng     Pagination:  268-70     Citation Subset:  IM    
Copyright Information:
Copyright 2010. Published by Elsevier SAS.
Service de rhumatologie, hôpital Roger-Salengro, CHRU de Lille, université de Lille-2, rue Emile-Laine, 59037 Lille cedex, France.
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MeSH Terms
Antirheumatic Agents / adverse effects*
Antitubercular Agents / adverse effects*
Contraceptives, Oral / adverse effects*
Drug Interactions
Immunocompromised Host
Isoniazid / adverse effects
Rifampin / adverse effects*
Spondylitis, Ankylosing / drug therapy*,  immunology
Tuberculosis, Pulmonary / immunology,  prevention & control*
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Reg. No./Substance:
0/Antirheumatic Agents; 0/Antitubercular Agents; 0/Contraceptives, Oral; 0/Tumor Necrosis Factor-alpha; 13292-46-1/Rifampin; 54-85-3/Isoniazid

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