Document Detail


Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.
MedLine Citation:
PMID:  17496195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Reproductive factors have been shown by epidemiology studies to alter colorectal cancer risk in women. Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple adenoma formation in the intestine. The Min mouse provides a good model of FAP, and we recently reported a significant increase in intestinal tumour multiplicity in a recombinant line of mice following pregnancy.
AIM: We considered whether reproduction modulates intestinal tract disease in a large cohort of female patients with FAP (n = 180).
RESULTS: Multiple regression analysis showed that the number of colonic polyps observed was not related to the person's pregnancy status nor the position of their APC germline mutation. The proportion of women attaining a high Spigelman stage (3 or 4) was unrelated to having a pregnancy prior to attaining the maximum Spigelman stage (p = 0.6). On the other hand, having a pregnancy significantly increased the proportion of women that attained the highest Spigelman stage when their APC germline mutation occurred within the mutation cluster region or at or after codon 1020 (50%, 6/12, p = 0.005 and 42%, 13/31, p = 0.006, respectively; multivariable logistic regression).
CONCLUSION: Our data suggest that reproduction may influence disease severity in the upper gastrointestinal tract in patients with FAP.
Authors:
Nirosha Suraweera; Andrew Latchford; Amy McCart; Pauline Rogers; Sarah Spain; Oliver Sieber; Robin Phillips; Ian Tomlinson; Andrew Silver
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Publication Detail:
Type:  Letter     Date:  2007-05-11
Journal Detail:
Title:  Journal of medical genetics     Volume:  44     ISSN:  1468-6244     ISO Abbreviation:  J. Med. Genet.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-03     Completed Date:  2007-09-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  2985087R     Medline TA:  J Med Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyposis Coli
Colectomy
Colonic Polyps / genetics*,  surgery
Female
Gastrointestinal Diseases / genetics*,  prevention & control
Genes, APC*
Germ-Line Mutation
Humans
Mutation
Pregnancy
Pregnancy Complications / genetics*
Regression Analysis
Siblings
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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