Document Detail

Pregnancy does not accelerate biological valve degeneration.
MedLine Citation:
PMID:  20605238     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Pregnancy in women with biological heart valve prosthesis might lead to a faster degeneration of the prosthesis. We analyzed the rate of prosthesis replacement and the outcome of pregnancies in women with biological valve prosthesis.
METHODS: Between 1976 and 2006, 100 female patients aged 18-40years at time of the study, underwent a valve replacement with a bioprosthesis or a homograft. At a mean interval of 10.8±8years, 87 patients were evaluated by a questionnaire.
RESULTS: A biological prosthesis was implanted in 45 patients (52%), while 42 patients (48%) received a homograft. After valve replacement, 33 patients (38%) had a total of 56 pregnancies with a live-birth rate of 77% (n=43). There were 9 (16%) miscarriages, 4 (7%) therapeutic abortions and no stillbirths. There was no maternal death, thromboembolic event or structural valve deterioration during pregnancy. Out of 87 patients, 31 (36%) required a valve re-replacement at a mean time of 9.5±5years. Neither age, valve type, valve position nor pregnancy were a risk factor for a valve re-replacement. The freedom from valve re-replacement at 5 and 10years, was 96±3% and 73±9%, respectively for patients after a pregnancy compared to 93±4% and 52±10%, respectively for patients without a pregnancy (p=0.2).
CONCLUSIONS: Pregnancy does not accelerate the risk for replacement of a biological heart valve prosthesis. Pregnancy in women with biological heart valves can be carried out without increased morbidity related to the implanted valve.
Julie Cleuziou; Jürgen Hörer; Harald Kaemmerer; Alexandra Teodorowicz; Jelena Kasnar-Samprec; Christian Schreiber; Rüdiger Lange
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Publication Detail:
Type:  Journal Article     Date:  2010-06-03
Journal Detail:
Title:  International journal of cardiology     Volume:  145     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  418-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiovascular Surgery, German Heart Center Munich, Technische Universität München, Germany.
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