Document Detail


Pregnancy and delivery outcomes following a pathological second trimester triple test screening result and a normal karyotype.
MedLine Citation:
PMID:  22873284     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To investigate whether obstetrical complications are increased in pregnancies with a normal karyotype and an abnormal triple test (TT) (≥1:380 or more) where all anylates were within the normal range. Methods: A retrospective cohort study of women who underwent a TT and delivered in a tertiary medical center, was conducted. Patients were divided into a study group (pregnancies with abnormal TT) and a control group (normal TT). In both groups the anylate concentrations were within the normal range and the karyotype was normal. Demographic and clinical characteristics, antenatal factors, gestational complications and perinatal outcomes were compared between the groups. Results: An abnormal TT result in the presence of normal analytes and a normal karyotype, had no impact on obstetrical complications. A direct association between elevated values of hCG within the normal range (0-2.0 MoM) and pathological TT was noticed (OR = 2.6, p < 0.01). On the other hand, an inverse correlation between elevation in AFP (0-2.0 MoM) and uE3 was found (OR < 0.01, p < 0.01; OR < 0.01, p < 0.01, respectively). Conclusions: An abnormal TT result in the presence of normal analytes and a normal karyotype, had no influence on rate of obstetrical complications.
Authors:
Adi Y Weintraub; Inbal Weiss; Michael Friger; Reli Hershkovitz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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