| Pregnancy- and delivery-induced biomechanical changes in rat vagina persist postpartum. | |
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MedLine Citation:
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PMID: 20424824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION AND HYPOTHESIS: We sought to define changes in vaginal distensibility (VD) induced by pregnancy and vaginal delivery using a novel in vivo biomechanical testing protocol. METHODS: Under sedation, a balloon was inserted into the vagina of 27 virgin, pregnant and 4-week postpartum Long-Evans rats and incrementally distended. Pressure-volume curves were generated with slopes characterizing VD (higher slope = less distensible). One-way ANOVA with a Bonferroni post-hoc test were used for statistical analyses. RESULTS: Mean pressures at an infusion volume of 1 cc were lower in pregnant and postpartum rats than in virgins (P < 0.001). VD was increased in pregnant vs. virgin rats (P < 0.001) and did not recover to virgin levels post partum (P < 0.001). CONCLUSIONS: We have developed a test that measures VD in vivo under clinically relevant loading conditions. The increased VD in the late postpartum period defines a persistent change in biomechanical behavior of the vagina related to pregnancy and vaginal delivery. |
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Authors:
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Marianna Alperin; Andrew Feola; Robert Duerr; Pamela Moalli; Steven Abramowitch |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-04-28 |
Journal Detail:
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Title: International urogynecology journal Volume: 21 ISSN: 1433-3023 ISO Abbreviation: Int Urogynecol J Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2011-04-05 Revised Date: 2011-08-18 |
Medline Journal Info:
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Nlm Unique ID: 101567041 Medline TA: Int Urogynecol J Country: England |
Other Details:
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Languages: eng Pagination: 1169-74 Citation Subset: IM |
Affiliation:
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Division of Urogynecology and Reconstructive Pelvic Surgery, University of Pittsburgh, Pittsburgh, PA, USA. manusha30@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Animals Biomechanics Female Postpartum Period / physiology* Pregnancy Pregnancy, Animal / physiology* Rats Rats, Long-Evans Vagina / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD043441-09/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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