Document Detail


Pregnancy- and delivery-induced biomechanical changes in rat vagina persist postpartum.
MedLine Citation:
PMID:  20424824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION AND HYPOTHESIS: We sought to define changes in vaginal distensibility (VD) induced by pregnancy and vaginal delivery using a novel in vivo biomechanical testing protocol.
METHODS: Under sedation, a balloon was inserted into the vagina of 27 virgin, pregnant and 4-week postpartum Long-Evans rats and incrementally distended. Pressure-volume curves were generated with slopes characterizing VD (higher slope = less distensible). One-way ANOVA with a Bonferroni post-hoc test were used for statistical analyses.
RESULTS: Mean pressures at an infusion volume of 1 cc were lower in pregnant and postpartum rats than in virgins (P < 0.001). VD was increased in pregnant vs. virgin rats (P < 0.001) and did not recover to virgin levels post partum (P < 0.001).
CONCLUSIONS: We have developed a test that measures VD in vivo under clinically relevant loading conditions. The increased VD in the late postpartum period defines a persistent change in biomechanical behavior of the vagina related to pregnancy and vaginal delivery.
Authors:
Marianna Alperin; Andrew Feola; Robert Duerr; Pamela Moalli; Steven Abramowitch
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-28
Journal Detail:
Title:  International urogynecology journal     Volume:  21     ISSN:  1433-3023     ISO Abbreviation:  Int Urogynecol J     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2011-04-05     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101567041     Medline TA:  Int Urogynecol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1169-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Animals
Biomechanical Phenomena
Female
Postpartum Period / physiology*
Pregnancy
Pregnancy, Animal / physiology*
Rats
Rats, Long-Evans
Vagina / physiology*
Grant Support
ID/Acronym/Agency:
K12 HD043441/HD/NICHD NIH HHS; K12 HD043441-09/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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