Document Detail

Pregnancy and delivery in penicillamine treated patients with Wilson's disease.
MedLine Citation:
PMID:  601776     Owner:  NLM     Status:  MEDLINE    
Pregnancy and delivery of two patients with Wilson's disease are reported. Case 1 was a 20-year-old housewife who had been taking D-penicillamine fore more than 10 years and had remained asymptomatic except an episode of dissociative reaction. She apparently survived longer than any of her three sisters who died of the same disease. She discontinued the use of D-penicillamine by herself when she was at the 22nd week of pregnancy. Case 2 was a 32-year-old housewife who developed an episode of mental disorder of short circuit reaction type with mild neurological symptoms and Kayser-Fleischer rings after the prolonged interval of medication since the first pregnancy and delivery. Three months after the complete recovery of neuropsychiatric symptoms she was at the 12th week of pregnancy and withheld penicillamine from herself. During the pregnancy they had not revealed any exacerbation in terms of clinical and laboratory findings. Each of them was delivered of a healthy baby. Although the pregnancy and delivery of both patients were successful, the authors recommended that they should not prolong the interval of medication to protect themselves against the onset or relapse of the illness.
K Fukuda; A Ishii; Y Matsue; K Funaki; H Hoshiai; S Maeda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  123     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-03-10     Completed Date:  1978-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  279-85     Citation Subset:  IM    
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MeSH Terms
Copper / metabolism
Hepatolenticular Degeneration / drug therapy*,  metabolism,  pathology
Labor, Obstetric*
Liver / pathology
Maternal-Fetal Exchange
Penicillamine / therapeutic use*
Pregnancy Complications / drug therapy*
Reg. No./Substance:
52-67-5/Penicillamine; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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