Document Detail

Pregnancy complications and birth outcomes of pregnant women with urinary tract infections and related drug treatments.
MedLine Citation:
PMID:  17464860     Owner:  NLM     Status:  MEDLINE    
Maternal urinary tract infections in pregnancy showed an association with a higher rate of preterm birth in previous studies. The aim of this study was to check this relationship, and in addition to evaluate the efficacy of recent medical treatments. The population-based large control (without any defects) data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities was evaluated. Of 38,151 newborn infants, 2188 (5.7%) had mothers with urinary tract infections during pregnancy, and 90% of these maternal diseases were prospectively and medically recorded. The prevalence of pre-eclampsia and polyhydramnios showed an association with urinary tract infections during pregnancy. Pregnant women with urinary tract infections in pregnancy had a somewhat shorter gestational age (0.1 week) and a higher proportion of preterm births (10.4% vs 9.1%). These differences were correlated with the severity of urinary tract infections. However, the preterm-inducing effect of maternal urinary tract infections is preventable by some antimicrobial drugs such as ampicillin, cefalexin and cotrimoxazole. In conclusion, maternal urinary tract infections during pregnancy increase pre-eclampsia and polyhydramnios, and in addition the rate of preterm birth; however, the latter is preventable by appropriate drug treatments.
Ferenc Bánhidy; Nándor Acs; Erzsébet H Puhó; Andrew E Czeizel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  39     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  390-7     Citation Subset:  IM    
Second Department of Obstetrics and Gynaecology, Semmelweis University, School of Medicine, Budapest, Hungary.
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MeSH Terms
Ampicillin / therapeutic use
Anti-Bacterial Agents / therapeutic use
Case-Control Studies
Cephalexin / therapeutic use
Health Surveys
Hungary / epidemiology
Infant, Newborn
Polyhydramnios / epidemiology*,  etiology
Pre-Eclampsia / epidemiology*,  etiology
Pregnancy Complications, Infectious / drug therapy*,  epidemiology
Pregnancy Outcome
Premature Birth / epidemiology,  etiology,  prevention & control
Prospective Studies
Retrospective Studies
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Urinary Tract Infections / complications*,  drug therapy*,  epidemiology
Reg. No./Substance:
0/Anti-Bacterial Agents; 15686-71-2/Cephalexin; 69-53-4/Ampicillin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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