Document Detail


Pregnancy complicating systemic lupus erythematosus: a series of 86 cases.
MedLine Citation:
PMID:  21136266     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the timing of pregnancy and pregnancy termination and its management in women with pregnancy complicating systemic lupus erythematosus (SLE).
METHODS: A series of 86 cases of pregnancy complicating SLE treated in our hospital from January 2005 to June 2010 were retrospectively reviewed, including 54 cases of planned pregnancy and 32 cases of unplanned pregnancy. The pregnancy courses and clinical outcomes were analyzed.
RESULTS: While 12 patients in planned pregnancy group showed active SLE during pregnancy, all 32 patients in the unplanned pregnancy group presented severe SLE complications. The incidences of pregnancy loss, preterm delivery and neonatal asphyxia in the unplanned pregnancy group were significantly higher than planned pregnancy group (P < 0.05), and the infant body weight was lower in the unplanned pregnancy group (P < 0.05). A total of 78 live infants were born and no mortality was reported, including 15 preterm infants and one neonatal SLE.
CONCLUSION: Planned pregnancy during stable stage, appropriate treatment in pregnancy and close monitoring can improve the security of pregnancy complicating SLE. In situations that the drug treatment is ineffective and the mother and infant are threatened, or the fetus is mature, the pregnancy should be terminated promptly, thereby reducing the complications, and increasing the success rate of pregnancy and perinatal survival rate.
Authors:
Qiang Wei; Yunwei Ouyang; Weiyue Zeng; Lijun Duan; Junli Ge; Hua Liao
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Publication Detail:
Type:  Journal Article     Date:  2010-12-07
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  284     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1067-71     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
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