| Pregnancy complicated with Alport syndrome: a good obstetric outcome and failure to diagnose an infant born to a mother with Alport syndrome by umbilical cord immunofluorescence staining. | |
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MedLine Citation:
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PMID: 20144175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alport syndrome is a familial progressive nephritis. The most frequent type is X-linked Alport syndrome, caused by genetic abnormalities in the alpha 5 chain of type IV collagen. Skin biopsy is a useful tool for diagnosing this disease. It is not well known how this syndrome affects pregnancy and how it is affected by pregnancy, or whether the umbilical cord may provide material for detecting this collagen abnormality. We report a primigravida with Alport syndrome with mild proteinuria who gave birth abdominally to a term male infant without deteriorating renal function during pregnancy. The umbilical cord from not only this infant but also from an Alport (-) control infant showed negative immunofluorescence staining for the alpha 5 chain of type IV collagen. Women with Alport syndrome without renal dysfunction may follow an uneventful obstetrical course until term. The cord may not be suitable for diagnosing Alport syndrome with immunofluorescence staining. |
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Authors:
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Shigeki Matsubara; Yoshihiko Ueda; Hisako Takahashi; Takashi Nagai; Tomoyuki Kuwata; Shigeaki Muto; Takehiko Yamaguchi; Toshihiro Takizawa; Mitsuaki Suzuki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 35 ISSN: 1447-0756 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-05-25 Revised Date: 2012-01-19 |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Australia |
Other Details:
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Languages: eng Pagination: 1109-14 Citation Subset: IM |
Affiliation:
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Departments of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi, Japan. matsushi@jichi.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Collagen Type IV / metabolism* Female Humans Infant, Newborn Male Microscopy, Fluorescence Nephritis, Hereditary / diagnosis*, metabolism, pathology Pregnancy Pregnancy Complications / diagnosis, metabolism, pathology* Pregnancy Outcome Umbilical Cord / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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