| Pregnancy complicated by triploidy: a comparison of the three karyotypes. | |
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MedLine Citation:
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PMID: 19391081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated triploid pregnancy to determine whether there are clinically important differences between the three karyotypes: 69,XXX, 69,XXY, and 69,XYY. Prospectively maintained cytogenetic databases at five tertiary care centers were retrospectively reviewed over a 10-year period to identify all triploid pregnancies. Targeted ultrasounds were reviewed to identify fetal and placental findings. Sonographic findings were compared by karyotype. There was a total of 549 triploid gestations; preimplantation genetic diagnosis (PGD) detected 413 triploid embryos, and the cytogenetic databases provided 136 clinical pregnancies with triploidy. In triploid embryos with PGD, the frequency of the 69,XYY karyotype was 8.7% (36/413), compared with 0.74% (1/136) during the first trimester of clinical pregnancies (p = 0.002). In clinical pregnancies, 60% (36/60) of 69,XXY fetuses survived the first trimester of development compared with 69% (52/75) of 69,XXX fetuses (p = NS). No clinically important differences were observed between 69,XXX and 69,XXY karyotypes in terms of type, number, or severity of fetal or placental anomalies. Gestations with a 69,XYY karyotype are found less frequently compared with gestations with a 69,XXX or 69,XXY karyotype. The decline in fetal survival of the 69,XYY triploid karyotype needs further investigation. There are significant abnormalities detected during prenatal sonography in most all clinically recognized cases of triploidy. Sonography cannot reliably distinguish between the 69,XXY and 69,XXX karyotypes. |
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Authors:
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Dennis T McWeeney; Santiago Munn??; Richard C Miller; Natalie A Cekleniak; Stephen A Contag; Joseph R Wax; William J Polzin; William J Watson |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-04-23 |
Journal Detail:
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Title: American journal of perinatology Volume: 26 ISSN: 1098-8785 ISO Abbreviation: Am J Perinatol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-16 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 641-5 Citation Subset: IM |
Copyright Information:
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Thieme Medical Publishers. |
Affiliation:
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Division of Maternal-Fetal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. mcweeney.dennis@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosome Aberrations Chromosomes, Human, X / genetics Chromosomes, Human, Y / genetics Cohort Studies Congenital Abnormalities / genetics, ultrasonography* Female Humans Incidence Karyotyping Polyploidy* Pregnancy Pregnancy Complications / genetics, ultrasonography* Pregnancy Outcome Pregnancy Trimester, Second Retrospective Studies Risk Assessment Sex Chromosomes / genetics* Ultrasonography, Doppler* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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