Document Detail

Pregnancy complicated by medulloblastoma with metastases to the placenta.
MedLine Citation:
PMID:  8469498     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Maternal malignancy may complicate as many as one in 1000 pregnancies. Rarely, the tumor may metastasize to the products of conception. We here describe a case of medulloblastoma metastatic to the placenta. CASE: A 21-year-old woman who had previously undergone resection of a posterior fossa medulloblastoma was admitted at 20 weeks' gestation complaining of low back pain. Investigation revealed medulloblastoma metastatic to the bone marrow. The pregnancy was prolonged to 29 weeks' gestation, at which time she was delivered by cesarean. The postoperative course was complicated by coagulopathy, massive bleeding, and pneumonia leading to death. Autopsy showed medulloblastoma metastatic to the bone marrow and placenta. CONCLUSION: Primary intracranial neoplasms may metastasize to the products of conception. The dramatic course of the disease in this patient may suggest that medulloblastoma is responsive to hormonal therapy.
R N Pollack; M Pollak; L Rochon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  81     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-05-13     Completed Date:  1993-05-13     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  858-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada.
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MeSH Terms
Bone Marrow Diseases / pathology
Brain Neoplasms / pathology*
Cesarean Section
Cranial Fossa, Posterior
Infant, Newborn
Medulloblastoma / pathology,  secondary*
Placenta Diseases / pathology*
Pregnancy Complications, Neoplastic / pathology*

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