| Pregnancy complicated by diffuse chorioamniotic hemosiderosis: obstetric features and influence on respiratory diseases of the infant. | |
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MedLine Citation:
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PMID: 18001443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To clarify the clinical features of pregnancy and neonatal respiratory problems associated with diffuse chorioamniotic hemosiderosis (DCH). METHODS: Sixteen singleton cases of DCH without chorioamnionitis (CAM) were retrospectively analyzed and compared with gestation- and birthweight-matched controls (32 cases of CAM and 32 cases of non-DCH-non-CAM). Maternal symptoms and respiratory problems of the infants were investigated. RESULTS: All 16 cases with DCH resulted in preterm delivery from 23 to 35 weeks' gestation. The presence of subchorionic hematoma in the first trimester (P < 0.001), recurrent vaginal bleeding (P < 0.001), brownish amniotic fluid (P < 0.001) and amniotic necrosis or degeneration (P < 0.001) were significantly more frequent in the DCH group compared to the CAM and non-DCH-non-CAM groups. The incidence of dry lung syndrome and persistent pulmonary hypertension of the newborn (PPHN) was significantly higher in the DCH group than in the CAM (P < 0.001) and non-DCH-non-CAM (P < 0.001) groups. CONCLUSION: Long-term exposure to degenerating red blood cells is supposed to damage amnion, fetal alveolar epithelial cells and fetal pulmonary arteries, and may lead to dry lung syndrome and PPHN in the infant complicated by DCH. |
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Authors:
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Shiro Yoshida; Akihiko Kikuchi; Sorahiro Sunagawa; Kimiyo Takagi; Yoshifumi Ogiso; Tatsuya Yoda; Tomohiko Nakamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 33 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Japan |
Other Details:
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Languages: eng Pagination: 788-92 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Center for Perinatal Medicine, Nagano Children's Hospital, Nagano, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amnion / pathology Case-Control Studies Chorion / pathology Female Gestational Age Hemosiderosis / complications* Humans Infant, Newborn Lung Diseases / etiology* Male Obstetric Labor, Premature / etiology* Persistent Fetal Circulation Syndrome / etiology Pregnancy Pregnancy Complications* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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