Document Detail

Pregnancy and childbirth in carriers of the lamin A/C-gene mutation.
MedLine Citation:
PMID:  20413395     Owner:  NLM     Status:  MEDLINE    
This retrospective case report describes 11 pregnancies in five women. All of the women were carriers of the lamin A/C gene mutation known to cause dilated cardiomyopathy, often together with atrioventricular conduction disturbances. The penetrance of these mutations is age-dependent but almost complete. We found no major adverse effects or worsening in the cardiac condition during or after the pregnancy in these patients. All babies were healthy except for one with a small ventricular septal defect, one diagnosed with tracheobronchomalasia, and one with a patent ductus arteriosus. None of these defects have been associated with lamin A/C mutations.
Eeva Palojoki; Maija Kaartinen; Risto Kaaja; Eeva Reissell; Satu Kärkkäinen; Johanna Kuusisto; Tiina Heliö
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-22
Journal Detail:
Title:  European journal of heart failure     Volume:  12     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-08-20     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  630-3     Citation Subset:  IM    
Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Cardiomyopathy, Dilated / genetics*
Lamin Type A / genetics*
Middle Aged
Pregnancy Complications, Cardiovascular / genetics*
Retrospective Studies
Reg. No./Substance:
0/Lamin Type A; 0/lamin C
Comment In:
Eur J Heart Fail. 2010 Jun;12(6):532-4   [PMID:  20498268 ]

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