| Pregnancy characteristics and maternal risk of breast cancer. | |
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MedLine Citation:
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PMID: 9799175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a population-based case-control study of parous women less than 45 years of age, we evaluated the relations of various pregnancy characteristics to maternal breast cancer risk. Cases (N = 1,239) diagnosed with in situ or invasive breast cancer from 1990 to 1992 in Atlanta, GA, Seattle/Puget Sound, WA, and five counties in central New Jersey, and population controls (N = 1,166) identified by random-digit dialing, were interviewed regarding the details of their pregnancies. We used logistic regression to estimate relative risks (RR) and 95% confidence intervals (CI) and to adjust for breast cancer risk factors. Women who reported nausea or vomiting in their first pregnancy had a slightly lower risk of breast cancer (RR = 0.87; 95% CI = 0.72-1.0). We found no strong or consistent associations for maternal risk related to gestational length, pregnancy weight gain, gestational diabetes, pregnancy hypertension, or gender of the offspring, although we found some evidence for reductions in risk for toxemia (RR = 0.81; 95% CI = 0.61-1.1) and specific sex (RR for female twins vs singletons = 0.48; 95% CI = 0.20-1.3) and timing characteristics of twinning. Overall, these data provide little support for the hypothesis that pregnancy hormone levels are associated with subsequent maternal risk of breast cancer in young women. |
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Authors:
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R Troisi; H A Weiss; R N Hoover; N Potischman; C A Swanson; D R Brogan; R J Coates; M D Gammon; K E Malone; J R Daling; L A Brinton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 9 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-25 Completed Date: 1999-01-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 641-7 Citation Subset: IM |
Affiliation:
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7374, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Neoplasms / epidemiology*, etiology Case-Control Studies Female Gestational Age Humans Pregnancy* Pregnancy Complications / epidemiology* Pregnancy Proteins / pharmacology Risk Factors Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Pregnancy Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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