Document Detail


Pregnancy, but not the allergic status, influences spontaneous and induced interleukin-1beta (IL-1beta), IL-6, IL-10 and IL-12 responses.
MedLine Citation:
PMID:  16764689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we investigated how pregnancy influences cytokine production in response to stimulation of the innate and the adaptive immune system, respectively. Peripheral blood mononuclear cells (PBMCs) from allergic (n = 44) and non-allergic (n = 36) women were collected at three time-points: during the third trimester, at delivery and at a non-pregnant state 2 years after delivery. The production of interleukin-1beta (IL-1beta), IL-6, IL-10 and IL-12 was measured by enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunospot assay (ELISPOT). The spontaneous cytokine production, and the response following stimulation with agents that primarily activate the adaptive part of the immune system [phytohaemagglutinin (PHA), allergen extracts from cat and birch], or lipopolysaccharide (LPS) that activate innate immunity was measured in vitro. There was a significantly higher spontaneous in vitro production of IL-1beta, IL-6 and IL-10 by PBMCs during pregnancy than 2 years after pregnancy, and this was not affected by the allergic status of the women. Conversely, in PHA-stimulated cell cultures there was a lower production of IL-10 and IL-12 during pregnancy than 2 years after pregnancy. LPS-induced IL-6 levels were significantly lower in PBMCs obtained during pregnancy than at 2 years after pregnancy. In addition, we made the interesting observation that in allergic women total immunoglobulin E (IgE) levels were significantly lower 2 years after pregnancy compared to the levels during pregnancy. Taken together, our results indicate that while atopic allergy in women does not have a substantial effect on cytokine production, pregnancy has an obvious effect on the immune system in terms of cytokine production as well as on the total IgE levels.
Authors:
Petra Amoudruz; Jacob Taku Minang; Yvonne Sundström; Caroline Nilsson; Gunnar Lilja; Marita Troye-Blomberg; Eva Sverremark-Ekström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-08
Journal Detail:
Title:  Immunology     Volume:  119     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-23     Completed Date:  2007-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  18-26     Citation Subset:  IM    
Affiliation:
Department of Immunology, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. petra.amoudruz@imun.su.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / pharmacology
Case-Control Studies
Cells, Cultured
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
Hypersensitivity / immunology*
Immunoglobulin E / blood
Immunoglobulin G / blood
Interleukin-10 / immunology
Interleukin-12 / immunology
Interleukin-1beta / immunology
Interleukin-6 / immunology
Interleukins / immunology*
Labor, Obstetric / immunology
Leukocytes, Mononuclear / immunology*
Lipopolysaccharides / pharmacology
Postpartum Period / immunology
Pregnancy
Pregnancy Complications / immunology*
Pregnancy Trimester, Third
Statistics, Nonparametric
Tetradecanoylphorbol Acetate / pharmacology
Chemical
Reg. No./Substance:
0/Allergens; 0/Immunoglobulin G; 0/Interleukin-1beta; 0/Interleukin-6; 0/Interleukins; 0/Lipopolysaccharides; 130068-27-8/Interleukin-10; 16561-29-8/Tetradecanoylphorbol Acetate; 187348-17-0/Interleukin-12; 37341-29-0/Immunoglobulin E
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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