Document Detail

Pregnancy and breastfeeding in patients with Crohn's disease.
MedLine Citation:
PMID:  18239407     Owner:  NLM     Status:  MEDLINE    
Crohn's disease commonly affects women of childbearing age. Available data on Crohn's disease and pregnancy show that women with Crohn's disease can expect to conceive successfully, carry to term and deliver a healthy baby. Control of disease activity before conception and during pregnancy is critical, to optimize both maternal and fetal health. Generally speaking, pharmacological therapy for Crohn's disease during pregnancy is similar to pharmacological therapy for nonpregnant patients. Patients maintained in remission by way of pharmacological therapy should continue it throughout their pregnancy. Sulfasalazine, mesalazine and corticosteroids are safe, azathioprine and 6-mercaptopurine are reasonably safe with few discordant data, infliximab seems safe as well, whereas methotrexate is contraindicated during pregnancy. During breastfeeding, mesalazine and prednisone are considered safe, azathioprine/6-mercaptopurine, budesonide and infliximab probably safe and methotrexate is contraindicated.
Christian Mottet; Pascal Juillerat; Valérie Pittet; Jean-Jacques Gonvers; Florian Froehlich; John-Paul Vader; Pierre Michetti; Christian Felley
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-02-07
Journal Detail:
Title:  Digestion     Volume:  76     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2007  
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  149-60     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
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MeSH Terms
Anti-Infective Agents / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Breast Feeding*
Crohn Disease* / drug therapy
Drug Therapy, Combination
Glucocorticoids / therapeutic use
Immunologic Factors / therapeutic use
Pregnancy Complications* / drug therapy
Pregnancy Outcome
Reg. No./Substance:
0/Anti-Infective Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Glucocorticoids; 0/Immunologic Factors; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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