Document Detail


Pregnancy and autoimmunity: A common problem.
MedLine Citation:
PMID:  22424192     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Successful pregnancy is considered a Th1-Th2 cooperation phenomenon (Th, T-helper), with a predominantly Th2-type lymphocytes response, together with the emerging role of interleukin (IL)-12, IL-15 and IL-18 and of other unidentified soluble factors dependent on natural killer (NK) cells. In the pathogenesis of recurrent spontaneous abortion (RSA), immunological factors have been involved such as decidual cells, complement system, cytokines and genes of the hystocompatibility complex that can determine the success or the failure of a pregnancy. A deeper insight into apparently unexplained RSA shows increasing evidences supporting both alloimmune and autoimmune mechanisms, with autoantibodies playing a major role. The best-characterised pathogenic autoantibodies are anti-phospholipid antibodies, and also other autoantibodies, such as anti-Ro/SSA and anti-La/SSB, have been found to be associated with an increased rate of abortion, poor pregnancy outcome and several other obstetric manifestations. This intriguing mixture has been unveiled only in the last few years with the discovery of novel pathogenic mechanisms that can be targeted in the prevention and treatment of obstetrical complications occurring in the course of an autoimmune disease.
Authors:
Carlo Perricone; Caterina de Carolis; Roberto Perricone
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Best practice & research. Clinical rheumatology     Volume:  26     ISSN:  1532-1770     ISO Abbreviation:  Best Pract Res Clin Rheumatol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121149     Medline TA:  Best Pract Res Clin Rheumatol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  47-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Rome, Italy.
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