Document Detail


Pregnancy associated with lupus anticoagulant and heparin induced thrombocytopenia: management with a low molecular weight heparinoid.
MedLine Citation:
PMID:  1712988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The management of pregnant patients with coagulopathies and heparin induced thrombocytopenia is difficult and poorly defined. We report the case of a patient who was treated with a low molecular weight heparinoid. The treatment was complicated by the delayed occurrence of thrombocytopenia and a thrombotic event. This is the first report of thrombocytopenia caused by heparinoid. It is possible that this complication could have been avoided by a shorter duration of treatment with heparinoid and the use of Vitamin K antagonists during the second trimester of pregnancy.
Authors:
K van Besien; R Hoffman; A Golichowski
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  62     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-21     Completed Date:  1991-08-21     Revised Date:  2005-05-12    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
Affiliation:
Division of Hematology/Oncology, Indiana University Hospitals, Indianapolis 46202-5121.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation Disorders / complications,  drug therapy*,  immunology
Blood Coagulation Factors / analysis,  immunology
Chondroitin Sulfates*
Dermatan Sulfate*
Female
Glycosaminoglycans / therapeutic use*
Heparin / adverse effects*
Heparinoids / therapeutic use*
Heparitin Sulfate*
Humans
Lupus Coagulation Inhibitor
Pregnancy
Pregnancy Complications, Hematologic / chemically induced,  drug therapy*,  immunology
Thrombocytopenia / chemically induced,  complications,  drug therapy*
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Glycosaminoglycans; 0/Heparinoids; 0/Lupus Coagulation Inhibitor; 24967-94-0/Dermatan Sulfate; 83513-48-8/danaproid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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