Document Detail


Pregnancy-associated thrombotic thrombocytopenic purpura.
MedLine Citation:
PMID:  19190806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombocytopenia during pregnancy is a common diagnostic and management problem. Several differential diagnosis must be considered including manifestations of thrombotic thrombocytopenic purpura (TTP). We report here on a case of a 21-year-old pregnant woman who presented initially severe thrombocytopenia (8 Gpt/l) in the 20(th)+1 week of gestation. The patient had an antibody against ADAMTS13, and enzyme activity was <5%. Immediate plasmapheresis treatment was initiated, followed by plasma infusions, and again plasmapheresis. A male neonate was delivered by caesarean section in the 32(nd )week of gestation. The child had an uncomplicated postnatal development. After delivery, the mother's platelet count and ADAMTS13 activity increased to normal values. This case shows interesting aspects of TTP in pregnancy and a close cooperation between obstetricians, nephrologists and pediatricians is necessary for a successful outcome of the pregnancy.
Authors:
Jens Gerth; Ekkehard Schleussner; Karim Kentouche; Martin Busch; Mandy Seifert; Gunter Wolf
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  101     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  248-51     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D-07740 Jena, Germany.
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MeSH Terms
Descriptor/Qualifier:
ADAM Proteins / immunology
Autoantibodies / blood
Blood Component Transfusion
Cesarean Section
Female
Gestational Age
Humans
Infant, Newborn
Live Birth
Male
Patient Care Team
Plasmapheresis
Platelet Count
Pregnancy
Pregnancy Complications, Hematologic / diagnosis*,  immunology,  therapy
Purpura, Thrombotic Thrombocytopenic / diagnosis*,  immunology,  therapy
Ultrasonography, Doppler, Color
Ultrasonography, Prenatal / methods
Young Adult
von Willebrand Factor / metabolism
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/von Willebrand Factor; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human

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