| Pregnancy-associated thrombotic thrombocytopenic purpura. | |
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MedLine Citation:
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PMID: 19190806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombocytopenia during pregnancy is a common diagnostic and management problem. Several differential diagnosis must be considered including manifestations of thrombotic thrombocytopenic purpura (TTP). We report here on a case of a 21-year-old pregnant woman who presented initially severe thrombocytopenia (8 Gpt/l) in the 20(th)+1 week of gestation. The patient had an antibody against ADAMTS13, and enzyme activity was <5%. Immediate plasmapheresis treatment was initiated, followed by plasma infusions, and again plasmapheresis. A male neonate was delivered by caesarean section in the 32(nd )week of gestation. The child had an uncomplicated postnatal development. After delivery, the mother's platelet count and ADAMTS13 activity increased to normal values. This case shows interesting aspects of TTP in pregnancy and a close cooperation between obstetricians, nephrologists and pediatricians is necessary for a successful outcome of the pregnancy. |
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Authors:
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Jens Gerth; Ekkehard Schleussner; Karim Kentouche; Martin Busch; Mandy Seifert; Gunter Wolf |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 101 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-04 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 248-51 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D-07740 Jena, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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immunology Autoantibodies / blood Blood Component Transfusion Cesarean Section Female Gestational Age Humans Infant, Newborn Live Birth Male Patient Care Team Plasmapheresis Platelet Count Pregnancy Pregnancy Complications, Hematologic / diagnosis*, immunology, therapy Purpura, Thrombotic Thrombocytopenic / diagnosis*, immunology, therapy Ultrasonography, Doppler, Color Ultrasonography, Prenatal / methods Young Adult von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/von Willebrand Factor; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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