| Pregnancy-associated thrombocytopenia: definition, incidence and natural history. | |
| | |
MedLine Citation:
|
PMID: 2117324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have sought to clarify the definition and importance of newly diagnosed thrombocytopenia in pregnant women by establishing an appropriate reference interval for the platelet count, and by observing the outcome in a cohort of thrombocytopenic pregnant women. The mean platelet count was lower in 2,155 healthy pregnant than non-pregnant women, and varied with race, but did not fall with increasing gestation, except in Black women. 101 of approximately 2,800 women became newly thrombocytopenic during pregnancy by conventional criteria (platelets less than 150 x 10(9)/l), without an apparent cause. Using the reference intervals established during the study, however, 24 of these women would not have been regarded as thrombocytopenic. No bleeding tendency was observed in the mothers or their infants. Maternal platelet counts became normal in the postnatal period. Thrombocytopenia occurring for the first time during pregnancy may be a different condition from auto-immune thrombocytopenia, and we suggest the term 'pregnancy-associated thrombocytopenia' (PAT). PAT does not appear to be epidemic; it does not threaten the fetus, but it cannot be distinguished from auto-immune thrombocytopenia in individual cases. |
| | |
Authors:
|
J H Matthews; S Benjamin; D S Gill; N A Smith |
Related Documents
:
|
15488124 - Increased serum levels of neopterin and soluble interleukin-2 receptor in intrahepatic ... 16787664 - Maternal infection and white matter toxicity. 11513544 - Preeclampsia, a pregnancy-specific disease, is associated with fetal monocyte activation. 3238604 - Teratological assessment of exposure to time-varying magnetic field. 65334 - Determination of alpha-fetoprotein by a new paper disc radioimmunoassay of the sandwich... 3912504 - Active anti-paternal immunization does not affect the success of marsupial pregnancy. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Acta haematologica Volume: 84 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-09-20 Completed Date: 1990-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 24-9 Citation Subset: IM |
Affiliation:
|
Department of Haematology, St. Mary's Hospital Medical School, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Platelets
/
immunology Complement System Proteins / analysis Female Humans Immunoglobulin G / analysis Immunoglobulin M / analysis Incidence Platelet Count Pregnancy Pregnancy Complications, Hematologic / blood*, epidemiology, ethnology, immunology Pregnancy Outcome / epidemiology, ethnology Thrombocytopenia / blood*, epidemiology, ethnology, immunology |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G; 0/Immunoglobulin M; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas...
Next Document: Aberrance and modification of alpha-1- and alpha-2-globin gene expression in human and mouse erythro...