Document Detail


Pregnancy-associated severe liver dysfunction.
MedLine Citation:
PMID:  15388201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Determining the cause of liver disease in pregnancy can present a difficult challenge for clinicians. Minor elevations in aminotransferases may be a harbinger of life-threatening processes, such as acute fatty liver of pregnancy (AFLP) or hemolysis, elevated liver enzyme levels, low platelet count (HELLP) syndrome. Preeclampsia, HELLP syndrome, and AFLP form a spectrum of disease that ranges from involving mild symptoms to severe life-threatening multiorgan system dysfunction. They have been shown to be the primary causes of severe hepatic dysfunction during pregnancy. This article attempts to define the clinical and diagnostic features, pathophysiology, and treatment options of these diseases.
Authors:
Jay S Steingrub
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care clinics     Volume:  20     ISSN:  0749-0704     ISO Abbreviation:  Crit Care Clin     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-24     Completed Date:  2004-11-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8507720     Medline TA:  Crit Care Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  763-76, xi     Citation Subset:  IM    
Affiliation:
Department of Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. jay.steingrub@bhs.org
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MeSH Terms
Descriptor/Qualifier:
Fatty Liver* / diagnosis,  physiopathology,  therapy
Female
HELLP Syndrome* / diagnosis,  physiopathology,  therapy
Humans
Liver Diseases* / diagnosis,  physiopathology,  therapy
Pre-Eclampsia* / diagnosis,  physiopathology,  therapy
Pregnancy
Pregnancy Complications* / diagnosis,  physiopathology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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