Document Detail

Pregnancy-associated plasma protein predicts outcomes of percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome.
MedLine Citation:
PMID:  20723985     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Pregnancy-associated plasma protein A (PAPP-A) may play an important role in the development of acute coronary syndrome. This study aimed to investigate the relationship between the levels of circulating PAPP-A and the mid-term outcomes of percutaneous coronary intervention (PCI) in patients with non-ST-elevation acute coronary syndrome.
METHODS: The circulating PAPP-A levels and high-sensitivity C-reactive protein before PCI were measured in 129 patients with single coronary artery stenosis. The end point of clinical follow-up was cardiac death, nonfatal myocardial infarction, target vessel revascularization, and rehospitalization for angina.
RESULTS: During the follow-up of an average of 20.3 ± 5.2 months, a cardiac event was recorded in 25 patients (19.4%). The levels of PAPP-A (29.85 ± 19.51 mIu/L vs 20.47 ± 14.33 mIu/L, P = .007) and high-sensitivity C-reactive protein (5.63 ± 2.13 mg/L vs 4.11 ± 1.28 mg/L, P = .014) in patients with cardiac events were higher than in those without cardiac events. PAPP-A ≥ 11.33 mIu/L has a strong predictive value for a combined end point (risk ratio = 4.1; 95% confidence interval, 1.0-16.2; P = .037). Patients with lower PAPP-A levels (<11.33 mIu/L) had higher event-free survivals than patients with higher PAPP-A levels (log rank = 9.334, P = .025).
CONCLUSION: Circulating PAPP-A levels predict the mid-term outcomes of PCI in patients with non-ST-elevation acute coronary syndrome and single-vessel stenosis.
Wei-Yi Mei; Zhi-Min Du; Qiang Zhao; Cheng-Heng Hu; Yi Li; Chu-Fan Luo; Gui-Fu Wu; Guo-Wei Chen; Le-Xin Wang
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Publication Detail:
Type:  Journal Article     Date:  2010-08-17
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  40     ISSN:  1527-3288     ISO Abbreviation:  Heart Lung     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e78-83     Citation Subset:  AIM; IM    
Copyright Information:
Crown Copyright © 2011. Published by Mosby, Inc. All rights reserved.
Department of Cardiology, Huangpu Division of The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China.
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